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2/9/2022 7:25:27 AM | Browse: 366 | Download: 1447
Publication Name World Journal of Gastroenterology
Manuscript ID 71456
Country/Territory Lithuania
Received
2021-09-13 17:16
Peer-Review Started
2021-09-13 17:17
To Make the First Decision
Return for Revision
2021-11-16 20:04
Revised
2021-11-19 12:00
Second Decision
2022-01-18 03:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-01-20 04:07
Articles in Press
2022-01-20 04:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-01-28 10:02
Publish the Manuscript Online
2022-02-09 07:25
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biochemistry & Molecular Biology
Manuscript Type Case Control Study
Article Title Atrophic gastritis and gastric cancer tissue miRNome analysis reveal hsa-miR-129-1 and hsa-miR-196a as potential early diagnostic biomarkers
Manuscript Source Unsolicited Manuscript
All Author List Greta Varkalaite, Evelina Vaitkeviciute, Ruta Inciuraite, Violeta Salteniene, Simonas Juzenas, Vytenis Petkevicius, Rita Gudaityte, Antanas Mickevicius, Alexander Link, Limas Kupčinskas, Marcis Leja, Juozas Kupcinskas and Jurgita Skieceviciene
ORCID
Author(s) ORCID Number
Greta Varkalaite http://orcid.org/0000-0003-3488-2171
Evelina Vaitkeviciute http://orcid.org/0000-0003-2525-1597
Ruta Inciuraite http://orcid.org/0000-0002-5806-6155
Violeta Salteniene http://orcid.org/0000-0002-7881-945X
Simonas Juzenas http://orcid.org/0000-0001-9293-0691
Vytenis Petkevicius http://orcid.org/0000-0002-1964-5226
Rita Gudaityte http://orcid.org/0000-0001-7489-8069
Antanas Mickevicius http://orcid.org/0000-0002-6208-7039
Alexander Link http://orcid.org/0000-0002-9514-4562
Limas Kupčinskas http://orcid.org/0000-0002-8689-9023
Marcis Leja http://orcid.org/0000-0002-0319-8855
Juozas Kupcinskas http://orcid.org/0000-0002-8760-7416
Jurgita Skieceviciene http://orcid.org/0000-0002-4893-6612
Funding Agency and Grant Number
Funding Agency Grant Number
the MULTIOMICS project that has received funding from European Social Fund 09.3.3-LMT-K-712-01-0130
Corresponding Author Jurgita Skieceviciene, PhD, Senior Researcher, Institute for Digestive Research, Lithuanian University of Health Sciences, A. Mickeviciaus street 9, Kaunas 44307, Lithuania. jurgita.skieceviciene@lsmuni.lt
Key Words Gastric cancer; Atrophic gastritis; Tumorigenesis; Helicobacter pylori; MicroRNAs; Biomarkers
Core Tip In this research we aimed to evaluate microRNAs profiles of premalignant and malignant stages of gastric cancer (GC). To date this is the first study analyzing atrophic gastritis (AG) and GC tissue miRNomes in the subjects of European origin using next-generation sequencing approach. We showed that hsa-miR-196a-5p expression in tissue is significant for discrimination between controls and AG or GC, while hsa-miR-129-1-3p is potential candidate for non-invasive GC diagnostic. This study provides novel insights into complex GC pathogenesis cascade and might be highly significant for future studies of new AG or GC associated epigenetic markers or even diagnostic targets.
Publish Date 2022-02-09 07:25
Citation Varkalaite G, Vaitkeviciute E, Inciuraite R, Salteniene V, Juzenas S, Petkevicius V, Gudaityte R, Mickevicius A, Link A, Kupcinskas L, Leja M, Kupcinskas J, Skieceviciene J. Atrophic gastritis and gastric cancer tissue miRNome analysis reveal hsa-miR-129-1 and hsa-miR-196a as potential early diagnostic biomarkers. World J Gastroenterol 2022; 28(6): 653-664
URL https://www.wjgnet.com/1007-9327/full/v28/i6/653.htm
DOI https://dx.doi.org/10.3748/wjg.v28.i6.653
Full Article (PDF) WJG-28-653.pdf
Full Article (Word) WJG-28-653.docx
Manuscript File 71456_Auto_Edited.docx
Answering Reviewers 71456-Answering reviewers.pdf
Audio Core Tip 71456-Audio core tip.m4a
Biostatistics Review Certificate 71456-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 71456-Conflict-of-interest statement.pdf
Copyright License Agreement 71456-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 71456-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 71456-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 71456-Institutional review board statement.PDF
Non-Native Speakers of English Editing Certificate 71456-Language certificate.pdf
Supplementary Material 71456-Supplementary material.pdf
Peer-review Report 71456-Peer-review(s).pdf
Scientific Misconduct Check 71456-Bing-Wang JJ-2.png
Scientific Editor Work List 71456-Scientific editor work list.pdf