ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Biochemistry & Molecular Biology |
Manuscript Type |
Case Control Study |
Article Title |
Atrophic gastritis and gastric cancer tissue miRNome analysis reveal hsa-miR-129-1 and hsa-miR-196a as potential early diagnostic biomarkers
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Greta Varkalaite, Evelina Vaitkeviciute, Ruta Inciuraite, Violeta Salteniene, Simonas Juzenas, Vytenis Petkevicius, Rita Gudaityte, Antanas Mickevicius, Alexander Link, Limas Kupčinskas, Marcis Leja, Juozas Kupcinskas and Jurgita Skieceviciene |
ORCID |
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Funding Agency and Grant Number |
Funding Agency |
Grant Number |
the MULTIOMICS project that has received funding from European Social Fund |
09.3.3-LMT-K-712-01-0130 |
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Corresponding Author |
Jurgita Skieceviciene, PhD, Senior Researcher, Institute for Digestive Research, Lithuanian University of Health Sciences, A. Mickeviciaus street 9, Kaunas 44307, Lithuania. jurgita.skieceviciene@lsmuni.lt |
Key Words |
Gastric cancer; Atrophic gastritis; Tumorigenesis; Helicobacter pylori; MicroRNAs; Biomarkers |
Core Tip |
In this research we aimed to evaluate microRNAs profiles of premalignant and malignant stages of gastric cancer (GC). To date this is the first study analyzing atrophic gastritis (AG) and GC tissue miRNomes in the subjects of European origin using next-generation sequencing approach. We showed that hsa-miR-196a-5p expression in tissue is significant for discrimination between controls and AG or GC, while hsa-miR-129-1-3p is potential candidate for non-invasive GC diagnostic. This study provides novel insights into complex GC pathogenesis cascade and might be highly significant for future studies of new AG or GC associated epigenetic markers or even diagnostic targets. |
Publish Date |
2022-02-09 07:25 |
Citation |
Varkalaite G, Vaitkeviciute E, Inciuraite R, Salteniene V, Juzenas S, Petkevicius V, Gudaityte R, Mickevicius A, Link A, Kupcinskas L, Leja M, Kupcinskas J, Skieceviciene J. Atrophic gastritis and gastric cancer tissue miRNome analysis reveal hsa-miR-129-1 and hsa-miR-196a as potential early diagnostic biomarkers. World J Gastroenterol 2022; 28(6): 653-664 |
URL |
https://www.wjgnet.com/1007-9327/full/v28/i6/653.htm |
DOI |
https://dx.doi.org/10.3748/wjg.v28.i6.653 |