Publication Name	World Journal of Clinical Cases
Manuscript ID	71512
Country	China

Received	2021-09-10 14:12
Peer-Review Started	2021-09-10 14:14
To Make the First Decision
Return for Revision	2022-01-18 01:08
Revised	2022-01-25 14:18
Second Decision	2022-07-18 03:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-07-22 02:09
Articles in Press	2022-07-22 02:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-07-29 03:06
Publish the Manuscript Online	2022-08-16 01:35

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Prospective Study
Article Title	Quantitative differentiation of malignant and benign thyroid nodules with multi-parameter diffusion-weighted imaging
Manuscript Source	Unsolicited Manuscript
All Author List	Xiang Zhu, Jia Wang, Yan-Chun Wang, Ze-Feng Zhu, Jian Tang, Xiao-Wei Wen, Ying Fang and Jun Han
ORCID	Author(s) ORCID Number Xiang Zhu http://orcid.org/0000-0001-7109-8349 Jia Wang http://orcid.org/0000-0002-3741-3816 Yan-Chun Wang http://orcid.org/0000-0002-4756-3367 Ze-Feng Zhu http://orcid.org/0000-0002-1328-1230 Jian Tang http://orcid.org/0000-0002-5180-0927 Xiao-Wei Wen http://orcid.org/0000-0001-8068-0074 Ying Fang http://orcid.org/0000-0002-9277-2037 Jun Han http://orcid.org/0000-0002-4821-0547
Funding Agency and Grant Number
Corresponding Author	Jun Han, MD, Associate Chief Physician, Department of Radiology, The First Hospital of Jiaxing & The Affiliated Hospital of Jiaxing University, No. 1882 Zhonghuan South Road, Jiaxing 314000, Zhejiang Province, China. 13706735435@163.com
Key Words	Thyroid nodule; Magnetic resonance imaging; Diffusion-weighted imaging; Quantitative study; Sensitivity; Specificity
Core Tip	Multiple diffusion coefficient parameters obtained by fitting with mono-exponential, bi-exponential, stretched exponential, and kurtosis diffusion-weighted imaging models are feasible techniques for investigating thyroid nodules; The metrics including D, distributed diffusion coefficient, Dapp and Kapp provide additional information with similar diagnostic performance of ADC, and combination of these metrics may contribute to differentiate benign and malignant thyroid nodules; The apparent diffusion coefficient calculated with a mono-exponential model using a single pair of conventional b values (b = 1000 s/mm2) have similar diagnostic performance to those calculated with higher b values (b value > 1000 s/mm2).
Publish Date	2022-08-16 01:35
Citation	Zhu X, Wang J, Wang YC, Zhu ZF, Tang J, Wen XW, Fang Y, Han J. Quantitative differentiation of malignant and benign thyroid nodules with multi-parameter diffusion-weighted imaging. World J Clin Cases 2022; 10(24): 8587-8598
URL	https://www.wjgnet.com/2307-8960/full/v10/i24/8587.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i24.8587

Full Article (PDF)	WJCC-10-8587.pdf
Full Article (Word)	WJCC-10-8587.docx
Manuscript File	71512_Auto_Edited-LJH-LS.docx
Answering Reviewers	71512-Answering reviewers.pdf
Audio Core Tip	71512-Audio core tip.m4a
Biostatistics Review Certificate	71512-Biostatistics statement.pdf
Clinical Trial Registration Statement	71512-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	71512-Conflict-of-interest statement.pdf
Copyright License Agreement	71512-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	71512-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	71512-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	71512-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	71512-Language certificate.pdf
Peer-review Report	71512-Peer-review(s).pdf
Scientific Misconduct Check	71512-CrossCheck.jpg
Scientific Editor Work List	71512-Scientific editor work list.pdf