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Articles Published Processes
6/24/2022 9:00:24 AM | Browse: 194 | Download: 458
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Received |
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2021-09-13 13:35 |
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Peer-Review Started |
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2021-09-13 13:36 |
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To Make the First Decision |
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Return for Revision |
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2022-01-10 08:56 |
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Revised |
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2022-01-19 14:12 |
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Second Decision |
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2022-05-07 07:56 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-05-08 07:08 |
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Articles in Press |
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2022-05-08 07:08 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-04-29 03:22 |
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Typeset the Manuscript |
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2022-05-23 02:23 |
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Publish the Manuscript Online |
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2022-06-24 09:00 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Case Report |
| Article Title |
Choroidal thickening with serous retinal detachment in BRAF/MEK inhibitor-induced uveitis: A case report
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Peter Kiraly, Alenka Lavrič Groznik, Nataša Vidovič Valentincic, Polona Jaki Mekjavic, Mojca Urbančič, Janja Ocvirk and Tanja Mesti |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Tanja Mesti, PhD, Assistant Professor, Medical oncology, Institute of Oncology Ljubljana, Zaloška 2, Ljubljana 1000, Ljubljana, Slovenia. tmesti@onko-i.si |
| Key Words |
Metastatic melanoma treatment; BRAF/MEK inhibitors; Dabrafenib and trametinib; Ocular adverse effects; Bilateral panuveitis; Case report |
| Core Tip |
The effectiveness of B-Raf proto-oncogene serine/threonine kinase (BRAF)/mitogen-activated protein kinase (MEK) inhibitor therapy in terms of prolonging survival has revolutionized the treatment of metastatic melanoma and other cancers. Consequently, widespread use in several metastatic cancers could be anticipated in the future. Therefore, all possible adverse effects should be described. We report a case of very rare and severe bilateral panuveitis with transient visual loss associated with treatment of metastatic malignant melanoma. The purpose of our case report is to raise awareness of possible severe bilateral panuveitis associated with immune checkpoint inhibitor therapy and to show that ocular symptoms subside with BRAF/MEK inhibitor discontinuation and/or systemic corticosteroids. Further studies should establish guidelines for panuveitis management and evaluate the importance of ophthalmological examination for asymptomatic patients. |
| Publish Date |
2022-06-24 09:00 |
| Citation |
Kiraly P, Groznik AL, Valentincic NV, Mekjavic PJ, Urbančič M, Ocvirk J, Mesti T. Choroidal thickening with serous retinal detachment in BRAF/MEK inhibitor-induced uveitis: A case report. World J Clin Cases 2022; 10(19): 6536-6542 |
| URL |
https://www.wjgnet.com/2307-8960/full/v10/i19/6536.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v10.i19.6536 |
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