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5/24/2022 2:32:32 PM | Browse: 284 | Download: 702
Publication Name World Journal of Clinical Cases
Manuscript ID 71574
Country China
Received
2021-09-13 13:39
Peer-Review Started
2021-09-13 13:41
To Make the First Decision
Return for Revision
2022-01-26 14:43
Revised
2022-02-02 03:28
Second Decision
2022-03-30 02:06
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2022-04-04 05:12
Articles in Press
2022-04-04 05:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
2022-03-26 23:56
Typeset the Manuscript
2022-05-11 09:23
Publish the Manuscript Online
2022-05-24 14:32
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biotechnology & Applied Microbiology
Manuscript Type Clinical and Translational Research
Article Title Glycolytic and fatty acid oxidation genes affect the treatment and prognosis of liver cancer
Manuscript Source Unsolicited Manuscript
All Author List Jia-Yue Zou, Yu-Jie Huang, Jun He, Zu-Xiong Tang and Lei Qin
ORCID
Author(s) ORCID Number
Jia-Yue Zou http://orcid.org/0000-0001-8491-6486
Yu-Jie Huang http://orcid.org/0000-0003-4773-8515
Jun He http://orcid.org/0000-0001-9877-2890
Zu-Xiong Tang http://orcid.org/0000-0002-8614-451X
Lei Qin http://orcid.org/0000-0002-9369-1132
Funding Agency and Grant Number
Funding Agency Grant Number
Project of National Natural Science Foundation of China 81802365
Project of National Natural Science Foundation of China 81802385
Special Project of Clinical Key Diseases Treatment Technology in Suzhou LCZX2019003
City-Level Scientific Research Projects in Jiangsu Province SLT201907
Major Projects of Provincial Universities in Jiangsu Province 19KJA170002
Soochow University Horizontal Research Project H190168
Corresponding Author Lei Qin, MD, Doctor, Doctor, Professor, Department of General Surgery, The First Affiliated Hospital of Soochow University, No. 899 Pinghai Road, Suzhou 215006, Jiangsu Province, China. qinleihbps@163.com
Key Words Metabolic reprogramming; Fatty acid oxidation; Tumour immune dysfunction and exclusion; Hepatocellular carcinoma; Nomogram
Core Tip Through cluster analysis, we divided liver cancer samples into four subgroups and compared survival and molecular biological differences between different subtypes. The median survival of the fatty acid oxidation group was significantly better than that of the glycolytic group. We used Lasso regression to reduce dimensionality and selected RAE1 and CTNNB1 for modelling. We found that the model can identify patients with a better response to anti-cancer drugs, such as Sorafenib and Paclitaxel, which can also guide clinical treatment.
Publish Date 2022-05-24 14:32
Citation Zou JY, Huang YJ, He J, Tang ZX, Qin L. Glycolytic and fatty acid oxidation genes affect the treatment and prognosis of liver cancer. World J Clin Cases 2022; 10(15): 4737-4760
URL https://www.wjgnet.com/2307-8960/full/v10/i15/4737.htm
DOI https://dx.doi.org/10.12998/wjcc.v10.i15.4737
Full Article (PDF) WJCC-10-4737.pdf
Full Article (Word) WJCC-10-4737.docx
Manuscript File 71574_Auto_Edited.docx
Answering Reviewers 71574-Answering reviewers.pdf
Audio Core Tip 71574-Audio core tip.mp3
Biostatistics Review Certificate 71574-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 71574-Conflict-of-interest statement.pdf
Copyright License Agreement 71574-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document 71574-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 71574-Language certificate.pdf
Peer-review Report 71574-Peer-review(s).pdf
Scientific Editor Work List 71574-Scientific editor work list.pdf
CrossCheck Report 71574-CrossCheck report.pdf