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Articles Published Processes
5/24/2022 2:32:32 PM | Browse: 284 | Download: 702
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Received |
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2021-09-13 13:39 |
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Peer-Review Started |
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2021-09-13 13:41 |
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To Make the First Decision |
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Return for Revision |
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2022-01-26 14:43 |
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Revised |
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2022-02-02 03:28 |
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Second Decision |
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2022-03-30 02:06 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-04-04 05:12 |
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Articles in Press |
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2022-04-04 05:12 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-03-26 23:56 |
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Typeset the Manuscript |
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2022-05-11 09:23 |
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Publish the Manuscript Online |
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2022-05-24 14:32 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biotechnology & Applied Microbiology |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Glycolytic and fatty acid oxidation genes affect the treatment and prognosis of liver cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jia-Yue Zou, Yu-Jie Huang, Jun He, Zu-Xiong Tang and Lei Qin |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Project of National Natural Science Foundation of China |
81802365 |
| Project of National Natural Science Foundation of China |
81802385 |
| Special Project of Clinical Key Diseases Treatment Technology in Suzhou |
LCZX2019003 |
| City-Level Scientific Research Projects in Jiangsu Province |
SLT201907 |
| Major Projects of Provincial Universities in Jiangsu Province |
19KJA170002 |
| Soochow University Horizontal Research Project |
H190168 |
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| Corresponding Author |
Lei Qin, MD, Doctor, Doctor, Professor, Department of General Surgery, The First Affiliated Hospital of Soochow University, No. 899 Pinghai Road, Suzhou 215006, Jiangsu Province, China. qinleihbps@163.com |
| Key Words |
Metabolic reprogramming; Fatty acid oxidation; Tumour immune dysfunction and exclusion; Hepatocellular carcinoma; Nomogram |
| Core Tip |
Through cluster analysis, we divided liver cancer samples into four subgroups and compared survival and molecular biological differences between different subtypes. The median survival of the fatty acid oxidation group was significantly better than that of the glycolytic group. We used Lasso regression to reduce dimensionality and selected RAE1 and CTNNB1 for modelling. We found that the model can identify patients with a better response to anti-cancer drugs, such as Sorafenib and Paclitaxel, which can also guide clinical treatment. |
| Publish Date |
2022-05-24 14:32 |
| Citation |
Zou JY, Huang YJ, He J, Tang ZX, Qin L. Glycolytic and fatty acid oxidation genes affect the treatment and prognosis of liver cancer. World J Clin Cases 2022; 10(15): 4737-4760 |
| URL |
https://www.wjgnet.com/2307-8960/full/v10/i15/4737.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v10.i15.4737 |
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