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Articles Published Processes
3/25/2022 7:42:31 AM | Browse: 386 | Download: 1186
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Received |
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2021-09-21 10:40 |
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Peer-Review Started |
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2021-09-21 10:42 |
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To Make the First Decision |
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Return for Revision |
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2021-11-07 06:39 |
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Revised |
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2021-11-22 09:58 |
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Second Decision |
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2022-02-15 03:19 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-02-16 07:12 |
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Articles in Press |
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2022-02-16 07:12 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-02-14 03:54 |
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Typeset the Manuscript |
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2022-03-18 01:02 |
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Publish the Manuscript Online |
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2022-03-25 07:42 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Anesthesiology |
| Manuscript Type |
Basic Study |
| Article Title |
Spinal anesthesia alleviates dextran sodium sulfate-induced colitis by modulating the gut microbiota
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yu Hong, Jie Zhao, Ye-Ru Chen, Zi-Hao Huang, Li-Dan Hou, Bo Shen and Yu Xin |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Zhejiang Provincial Natural Science Foundation |
LY19H030011, LQ20C010005, LQ19H030009 |
| Key Project of Province and Ministry Foundation |
WKJZJ2124 |
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| Corresponding Author |
Yu Xin, PhD, Attending Doctor, Chief Physician, Department of Anesthesiology, Sir Run Run Shaw Hospital of Zhejiang University, No. 3 Qingchun Road, Hangzhou 310012, Zhejiang Province, China. xinxin_yu@zju.edu.cn |
| Key Words |
Spinal anesthesia; Inflammatory bowel disease; Gut microbiota; Intestinal barrier; Intestinal inflammation; Intestinal immune |
| Core Tip |
Inflammatory bowel disease (IBD) is a chronic inflammation with rising trends, but the pathogenesis is still not well understood. The effects of the gut microbiota, particularly the bi-directional interaction between brain and gut microbiota, have gradually attracted increasing attention. In the present study, we found that spinal anesthesia, a regional sympathetic block, alleviated the intestinal inflammation, maintained immunological function, and improved intestinal barrier function by modulating the gut microbiota. And reducing the increase of noradrenaline level in dextran sodium sulfate-treated mice by spinal anesthesia could be one of the mechanisms. The study highlights a novel approach for the treatment of IBD. |
| Publish Date |
2022-03-25 07:42 |
| Citation |
Hong Y, Zhao J, Chen YR, Huang ZH, Hou LD, Shen B, Xin Y. Spinal anesthesia alleviates dextran sodium sulfate-induced colitis by modulating the gut microbiota. World J Gastroenterol 2022; 28(12): 1239-1256 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i12/1239.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i12.1239 |
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