Publication Name	World Journal of Gastroenterology
Manuscript ID	71686
Country	China

Received	2021-09-18 01:33
Peer-Review Started	2021-09-18 01:35
To Make the First Decision
Return for Revision	2021-12-04 07:23
Revised	2021-12-15 15:38
Second Decision	2022-07-06 08:11
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-07-11 18:39
Articles in Press	2022-07-11 18:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-07-25 02:48
Publish the Manuscript Online	2022-08-03 07:54

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Integrative & Complementary Medicine
Manuscript Type	Basic Study
Article Title	Qingyi decoction attenuates intestinal epithelial cell injury via the calcineurin/nuclear factor of activated T-cells pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Guan-Yu Wang, Dong Shang, Gui-Xin Zhang, Hui-Yi Song, Nan Jiang, Huan-Huan Liu and Hai-Long Chen
ORCID	Author(s) ORCID Number Guan-Yu Wang http://orcid.org/0000-0002-9982-8785 Dong Shang http://orcid.org/0000-0001-6156-5214 Gui-Xin Zhang http://orcid.org/0000-0003-0125-6609 Hui-Yi Song http://orcid.org/0000-0003-3415-9223 Nan Jiang http://orcid.org/0000-0002-0613-5729 Huan-Huan Liu http://orcid.org/0000-0002-2023-8708 Hai-Long Chen http://orcid.org/0000-0001-5547-5837
Funding Agency and Grant Number	Funding Agency Grant Number National Key R and D Program of China 2019YFE0119300 National Natural Science Foundation of China 82074158 Project funded by China Postdoctoral Science Foundation 2018M631793 Natural Science Foundation of Liaoning Province 2019-ZD-0624 Dalian Traditional Chinese Medicine-Related Scientific Research Project 18Z2002
Corresponding Author	Hai-Long Chen, PhD, Chief Physician, Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Dalian 116011, Liaoning Province, China. hailongchen2014@yeah.net
Key Words	Severe acute pancreatitis; Intestinal epithelial cell; Apoptosis; Calcineurin/nuclear factor of activated T-cells pathway; Qingyi decoction
Core Tip	This manuscript investigated the role of the calcineurin (CaN)/nuclear factor of activated T-cells (NFATc3) pathway in the apoptosis of intestinal epithelial cells (IECs) in severe acute pancreatitis (SAP) and the potential mechanisms underlying the therapeutic effect of Qingyi decoction (QYD). QYD significantly restrained CaN and NFATc3 gene expression in the intestine, ameliorated IEC apoptosis associated with SAP, and decreased the lipopolysaccharide-induced elevation in intracellular free Ca2+ levels and cell death. These findings suggest that the protective effects of QYD might be mediated, at least partially, by downregulating IEC apoptosis via the CaN/NFATc3 pathway.
Publish Date	2022-08-03 07:54
Citation	Wang GY, Shang D, Zhang GX, Song HY, Jiang N, Liu HH, Chen HL. Qingyi decoction attenuates intestinal epithelial cell injury via the calcineurin/nuclear factor of activated T-cells pathway. World J Gastroenterol 2022; 28(29): 3825-3837
URL	https://www.wjgnet.com/1007-9327/full/v28/i29/3825.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i29.3825

Full Article (PDF)	WJG-28-3825.pdf
Full Article (Word)	WJG-28-3825.docx
The ARRIVE Guidelines	71686-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	71686_Auto_Edited-LS.docx
Answering Reviewers	71686-Answering reviewers.pdf
Audio Core Tip	71686-Audio core tip.mp3
Biostatistics Review Certificate	71686-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	71686-Conflict-of-interest statement.pdf
Copyright License Agreement	71686-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	71686-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	71686-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	71686-Language certificate.pdf
Peer-review Report	71686-Peer-review(s).pdf
Scientific Misconduct Check	71686-Bing-Wang JJ-2.png
Scientific Editor Work List	71686-Scientific editor work list.pdf
CrossCheck Report	71686-CrossCheck report.pdf