Publication Name	World Journal of Hematology
Manuscript ID	71725
Country	China

Received	2021-09-29 07:44
Peer-Review Started	2021-09-29 07:45
To Make the First Decision
Return for Revision	2021-12-02 07:38
Revised	2021-12-09 13:44
Second Decision	2022-02-11 05:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-02-13 17:01
Articles in Press	2022-02-13 17:01
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-01-17 00:18
Typeset the Manuscript	2022-02-21 13:10
Publish the Manuscript Online	2022-02-23 06:44

ISSN	2218-6204 (online)
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Category	Hematology
Manuscript Type	Case Report
Article Title	Efficacy of HA330-II column hemoadsorption in Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis combined with liver failure: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Qian Gao, Xiao-Wei Xin, Chun Zhao, Yu-Juan Wang, Wei Wang, Yi Yin, Xiao-Ru Wang and You-Peng Jin
ORCID	Author(s) ORCID Number Qian Gao http://orcid.org/0000-0002-3261-6139 Xiao-Wei Xin http://orcid.org/0000-0002-3216-9375 Chun Zhao http://orcid.org/0000-0002-5405-9177 Yu-Juan Wang http://orcid.org/0000-0003-3103-7626 Wei Wang http://orcid.org/0000-0002-6031-8702 Yi Yin http://orcid.org/0000-0002-4411-6000 Xiao-Ru Wang http://orcid.org/0000-0003-0386-6160 You-Peng Jin http://orcid.org/0000-0002-6357-2810
Funding Agency and Grant Number	Funding Agency Grant Number Clinical Science and Technology Innovation Scheme of Jinan Province 202019177 Clinical Science and Technology Innovation Scheme of Jinan Province 201704071
Corresponding Author	You-Peng Jin, PhD, Chief Doctor, Pediatric intensive care unit, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324 Jingwu Road, Huaiyin District , Jinan 250021, Shandong Province, China. jinyp79@sina.cn
Key Words	Hemoadsorption; HA330-II column; Hemophagocytic lymphohistiocytosis; Pediatric; Liver failure; Case report
Core Tip	Hemophagocytic hymphohistiocytosis (HLH) is an often fatal disease. We report an 11-year-old female who was diagnosed with Epstein-Barr virus-HLH and presented with coagulation disorders, liver damage, and respiratory insufficiency. In the present case, initially elevated interleukin (IL)-6, IL-8, IL-10, and interferon-γ levels were reduced to within normal ranges following hemoadsorption with HA330-II, and the patient’s condition gradually improved. HA330-II hemoadsorption has the ability to bridge the patient until chemotherapy can contribute to reduced HLH disease activity.
Publish Date	2022-02-23 06:44
Citation	Gao Q, Xin XW, Zhao C, Wang YJ, Wang W, Yin Y, Wang XR, Jin YP. Efficacy of HA330-II column hemoadsorption in Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis combined with liver failure: A case report. World J Hematol 2022; 9(1): 6-12
URL	https://www.wjgnet.com/2218-6204/full/v9/i1/6.htm
DOI	https://dx.doi.org/10.5315/wjh.v9.i1.6

Full Article (PDF)	WJH-9-6.pdf
Full Article (Word)	WJH-9-6.docx
Manuscript File	71725_Auto_Edited-XRG-Filipodia.docx
Answering Reviewers	71725-Answering reviewers.pdf
Audio Core Tip	71725-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	71725-Conflict-of-interest statement.pdf
Copyright License Agreement	71725-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	71725-Grant application form(s).pdf
Signed Consent for Treatment Form(s) or Document(s)	71725-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	71725-Language certificate.pdf
Peer-review Report	71725-Peer-review(s).pdf
Scientific Misconduct Check	71725-Bing-Guo XR-2.png
Scientific Editor Work List	71725-Scientific editor work list.pdf
CrossCheck Report	71725-CrossCheck report.pdf