Publication Name	World Journal of Gastroenterology
Manuscript ID	7184
Country	United States

Received	2013-11-07 14:12
Peer-Review Started	2013-11-08 16:17
To Make the First Decision	2013-12-16 18:10
Return for Revision	2013-12-20 17:44
Revised	2014-01-08 04:24
Second Decision	2014-04-16 11:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-04-16 12:11
Articles in Press	2014-05-23 09:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-06-26 18:14
Publish the Manuscript Online	2014-07-21 17:17

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Randomized Clinical Trial
Article Title	Routine use of thiopurines in maintaining remission in pediatric Crohn’s disease
Manuscript Source	Invited Manuscript
All Author List	Brendan M Boyle, Michael D Kappelman, Richard B Colletti, Robert N Baldassano, David E Milov and Wallace V Crandall
Funding Agency and Grant Number
Corresponding Author	Brendan M Boyle, MD, MPH, Nationwide Children’s Hospital, 700 Children’s Drive, Columbus, OH 43205, United States. brendan.boyle@nationwidechildrens.org
Key Words	Crohn’s disease; Pediatric; Remission; Thiopurines; Mercaptopurine
Core Tip	This manuscript describes the real world effectiveness of thiopurines in maintaining remission for pediatric Crohn’s disease. The outcomes differ in comparison to the initially published randomized controlled trial for pediatric Crohn’s but are similar to more recently published studies evaluating the effectiveness of thiopurines. The study evaluates data from a pediatric inflammatory bowel disease registry and is representative of real world clinical care. Varitation in practitioner approach to thiopurine dosage and metabolite measurement was found. Implementation of a more standardized approach to use of thiopurines could impact clinical outcomes.
Publish Date	2014-07-21 17:17
Citation	Boyle BM, Kappelman MD, Colletti RB, Baldassano RN, Milov DE, Crandall WV. Routine use of thiopurines in maintaining remission in pediatric Crohn’s disease. World J Gastroenterol 2014; 20(27): 9185-9190
URL	http://www.wjgnet.com/1007-9327/full/v20/i27/9185.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i27.9185

Full Article (PDF)	WJG-20-9185.pdf
Full Article (Word)	WJG-20-9185.doc
Manuscript File	7184-Review.doc
Answering Reviewers	7184-Answering reviewers.pdf
Copyright License Agreement	7184-Copyright assignment.pdf
Peer-review Report	7184-Peer reviewer(s).pdf
Scientific Editor Work List	7184-Scientific editor work list.doc