Publication Name	World Journal of Gastroenterology
Manuscript ID	7185
Country	China

Received	2013-11-07 14:18
Peer-Review Started	2013-11-08 15:34
First Decision by Editorial Office Director
Return for Revision	2014-01-20 17:29
Revised	2014-02-10 00:47
Publication Fee Transferred
Second Decision by Editor	2014-05-19 11:03
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-05-19 11:22
Articles in Press	2014-05-23 10:31
Edit the Manuscript by Language Editor	2014-05-29 08:17
Typeset the Manuscript	2014-09-12 16:05
Publish the Manuscript Online	2014-10-01 20:25

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Integrative & Complementary Medicine
Manuscript Type	Autobiography
Article Title	Xiaotan Sanjie decoction attenuates tumor angiogenesis by manipulating Notch-1-regulated proliferation of gastric cancer stem-like cells
Manuscript Source	Invited Manuscript
All Author List	Bing Yan, Long Liu, Ying Zhao, Li-Juan Xiu, Da-Zhi Sun, Xuan Liu, Ye Lu, Jun Shi, Yin-Cheng Zhang, Yong-Jin Li, Xiao-Wei Wang, Yu-Qi Zhou, Shou-Han Feng, Can Lv, Pin-Kang Wei and Zhi-Feng Qin
Funding Agency and Grant Number	Funding Agency Grant Number Project of Experimental Animal Research (the Science and Technology Commission of Shanghai) 13140901803
Corresponding Author	Zhi-Feng Qin, MD, Department of Traditional Chinese Medicine, Changzheng Hospital, the Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China. yanbing3741@gmail.com
Key Words	Gastric cancer stem-like cells; Xiaotan Sanjie decoction; Tumor angiogenesis; Notch-1; Vascular endothelial growth factor
Core Tip	Cancer stem-like cells (CSCs) are involved in tumor angiogenesis and have a higher capacity for secreting vascular endothelial growth factor (VEGF) than non-CSCs. Notch-1 was important in the control of the proliferation of many CSCs; targeting Notch-1 could result in a reduced CSC pool size and decreased levels of VEGF. Our study indicated that CD44+ GCSCs showed superior proliferation and higher VEGF secretion than non-CSCs; these traits were accompanied by high expression of Notch-1. Xiaotan Sanjie decoction could inhibit the proliferation of GCSCs and down-regulate microvessel density in a dose-dependent manner, which could be at least partially explained by its role in manipulating Notch-1.
Publish Date	2014-10-01 20:25
Citation	Yan B, Liu L, Zhao Y, Xiu LJ, Sun DZ, Liu X, Lu Y, Shi J, Zhang YC, Li YJ, Wang XW, Zhou YQ, Feng SH, Lv C, Wei PK, Qin ZF. Xiaotan Sanjie decoction attenuates tumor angiogenesis by manipulating Notch-1-regulated proliferation of gastric cancer stem-like cells. World J Gastroenterol 2014; 20(36): 13105-13118
URL	http://www.wjgnet.com/1007-9327/full/v20/i36/13105.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i36.13105

Full Article (PDF)	WJG-20-13105.pdf
Full Article (Word)	WJG-20-13105.doc
Manuscript File	7185-Review.doc
Answering Reviewers	7185-Answering reviewers.pdf
Copyright License Agreement	7185-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7185-Language certification.pdf
Peer-review Report	7185-Peer review.pdf