| Category |
Integrative & Complementary Medicine |
| Manuscript Type |
Autobiography |
| Article Title |
Xiaotan Sanjie decoction attenuates tumor angiogenesis by manipulating Notch-1-regulated proliferation of gastric cancer stem-like cells
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Bing Yan, Long Liu, Ying Zhao, Li-Juan Xiu, Da-Zhi Sun, Xuan Liu, Ye Lu, Jun Shi, Yin-Cheng Zhang, Yong-Jin Li, Xiao-Wei Wang, Yu-Qi Zhou, Shou-Han Feng, Can Lv, Pin-Kang Wei and Zhi-Feng Qin |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Project of Experimental Animal Research (the Science and Technology Commission of Shanghai) |
13140901803 |
|
| Corresponding Author |
Zhi-Feng Qin, MD, Department of Traditional Chinese Medicine, Changzheng Hospital, the Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China. yanbing3741@gmail.com |
| Key Words |
Gastric cancer stem-like cells; Xiaotan Sanjie decoction; Tumor angiogenesis; Notch-1; Vascular endothelial growth factor |
| Core Tip |
Cancer stem-like cells (CSCs) are involved in tumor angiogenesis and have a higher capacity for secreting vascular endothelial growth factor (VEGF) than non-CSCs. Notch-1 was important in the control of the proliferation of many CSCs; targeting Notch-1 could result in a reduced CSC pool size and decreased levels of VEGF. Our study indicated that CD44+ GCSCs showed superior proliferation and higher VEGF secretion than non-CSCs; these traits were accompanied by high expression of Notch-1. Xiaotan Sanjie decoction could inhibit the proliferation of GCSCs and down-regulate microvessel density in a dose-dependent manner, which could be at least partially explained by its role in manipulating Notch-1. |
| Publish Date |
2014-10-01 20:25 |
| Citation |
Yan B, Liu L, Zhao Y, Xiu LJ, Sun DZ, Liu X, Lu Y, Shi J, Zhang YC, Li YJ, Wang XW, Zhou YQ, Feng SH, Lv C, Wei PK, Qin ZF. Xiaotan Sanjie decoction attenuates tumor angiogenesis by manipulating Notch-1-regulated proliferation of gastric cancer stem-like cells. World J Gastroenterol 2014; 20(36): 13105-13118 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i36/13105.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i36.13105 |
