| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pathology |
| Manuscript Type |
Review |
| Article Title |
Pathological, molecular, and clinical characteristics of cholangiocarcinoma: A comprehensive review
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Mukul vij, Yogesh Puri, Ashwin Rammohan, Gowripriya G, Rajesh Rajalingam, Ilankumaran Kaliamoorthy and Mohamed Rela |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Mukul vij, MD, Doctor, Doctor, Pathology, Dr Rela institute and medical center, #7, CLC Works Road, Chromepet, Chennai, Tamil Nadu - 600 044., Chennai 600044, Tamil Nadu, India. mukul.vij.path@gmail.com |
| Key Words |
Cholangiocarcinoma; Classification; Pathology; Molecular features; Precursors lesions; Treatment |
| Core Tip |
Cholangiocarcinoma is a heterogeneous and aggressive epithelial malignancy of the biliary system. The majority of cholangiocarcinomas are diagnosed at an advanced stage when choice of treatment is limited. Cholangiocarcinoma is classified into intrahepatic, perihilar, and distal bile duct cancer, according to the anatomical location. This review focuses on the current knowledge of histopathological features, molecular alterations and clinical characteristics of cholangiocarcinoma and its precursor lesions (including biliary intraepithelial neoplasia, intraductal papillary neoplasms of the bile duct, intraductal tubulopapillary neoplasms and hepatobiliary mucinous cystic neoplasm. Recently, actionable genetic alterations, mainly IDH1 mutations and FGFR2 fusions have been described, in cholangiocarcinoma. |
| Publish Date |
2022-03-10 12:08 |
| Citation |
Vij M, Puri Y, Rammohan A, G G, Rajalingam R, Kaliamoorthy I, Rela M. Pathological, molecular, and clinical characteristics of cholangiocarcinoma: A comprehensive review. World J Gastrointest Oncol 2022; 14(3): 607-627 |
| URL |
https://www.wjgnet.com/1948-5204/full/v14/i3/607.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v14.i3.607 |
