Publication Name	World Journal of Gastroenterology
Manuscript ID	719
Country	China

Received	2012-10-03 23:38
Peer-Review Started	2012-10-05 20:35
To Make the First Decision	2013-01-17 11:06
Return for Revision	2013-01-17 16:58
Revised	2013-01-26 22:46
Second Decision	2013-03-22 12:01
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-03-23 09:42
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-04-24 15:49
Publish the Manuscript Online	2013-05-02 10:59

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Autobiography
Article Title	Emodin regulating excision repair cross-complementation group 1 through fibroblast growth factor receptor 2 signaling
Manuscript Source	Invited Manuscript
All Author List	Gang Chen, Hong Qiu, Shan-Dong Ke, Shao-Ming Hu, Shi-Ying Yu and Sheng-Quan Zou
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Sciences Foundation of China 81001067 the Ministry of Science and Technology International Cooperation Project 2010DFA31870 AstraZeneca Special Research Foundation for Targeted Therapy of the Wu Jieping Medical Foundation 320.6700.09068
Corresponding Author	Dr. Shao-Ming Hu, Integration Traditional Chinese Medicine and Western Medicine Department, TongJi Hospital, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Qiaokou District, Wuhan 430030, Hubei Province, China. smhu@tjh.tjmu.edu.cn
Key Words	Hepatocellular carcinoma; Emodin; Fibroblast growth factor receptor 2; Excision repair cross-complementation group 1; Platinum resistance; Extracellular signal-regulated kinase
Core Tip	In this study, our results indicated that emodin could significantly enhance the DNA damage caused by oxaliplatin (OXA) and induce OXA resistance reversal in HepG2/OXA cells. The molecular mechanism for this phenomenon is mediated by the inhibition of excision repair cross-complementing gene 1 expression by the fibroblast growth factor receptor 2/phosphorylated extracellular signal-regulated kinase 1/2 signaling pathway. The results for the reversal of platinum resistance by emodin and the emodin-based enhancement of the efficacy of platinum-based chemotherapy in hepatocellular carcinoma may provide an experimental basis for the further development and application of emodin in the reversal of platinum drug resistance in other types of malignant tumors.
Publish Date	2013-05-02 10:59
Citation	Chen G, Qiu H, Ke SD, Hu SM, Yu SY, Zou SQ. Emodin regulating excision repair cross-complementation group 1 through fibroblast growth factor receptor 2 signaling. World J Gastroenterol 2013; 19(16): 2481-2491
URL	http://www.wjgnet.com/1007-9327/full/v19/i16/2481.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i16.2481

Full Article (PDF)	WJG-19-2481.pdf
Manuscript File	719-Review.doc
Answering Reviewers	719-Answering reviewers.doc
Copyright License Agreement	719-Copyright assignment.doc
Non-Native Speakers of English Editing Certificate	719-Language cetificate.pdf
Peer-review Report	719-Peer review.pdf
Scientific Editor Work List	719-Scientific editor work list.doc