Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	71964
Country	Portugal

Received	2021-09-27 22:31
Peer-Review Started	2021-09-27 22:34
To Make the First Decision
Return for Revision	2021-12-04 20:40
Revised	2021-12-18 20:46
Second Decision	2022-02-17 05:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-02-20 13:15
Articles in Press	2022-02-20 13:15
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-01-22 12:42
Typeset the Manuscript	2022-03-02 23:31
Publish the Manuscript Online	2022-03-10 12:08

ISSN	1948-5204 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Colorectal cancer carcinogenesis: From bench to bedside
Manuscript Source	Invited Manuscript
All Author List	Pedro Currais, Isadora Rosa and Isabel Claro
ORCID	Author(s) ORCID Number Pedro Currais http://orcid.org/0000-0003-1470-655X Isadora Rosa http://orcid.org/0000-0002-2953-5987 Isabel Claro http://orcid.org/0000-0002-1860-6161
Funding Agency and Grant Number
Corresponding Author	Isadora Rosa, PhD, Doctor, Gastroenterology, Instituto Portugues de Oncologia de Lisboa Francisco Gentil, Rua Prof. Lima Basto, Lisboa 1099-023, Portugal. isarosa@ipolisboa.min-saude.pt
Key Words	Colorectal cancer; Carcinogenesis pathways; Microsatellite instability; APC; KRAS; BRAF
Core Tip	Colorectal cancer (CRC) is a major cause of cancer death worldwide. It is a heterogeneous entity and its molecular and genetic features have clinical implications. Three main carcinogenesis pathways, with some overlapping features, are now known to lead to CRC: Chromosomal instability, microsatellite instability, and the “serrated” pathways. Their features, namely, microsatellite instability status and BRAF or KRAS mutation status, among others, have to be studied to assess familial cancer risk and to make adequate therapy choices. Ongoing research will potentially even enlarge basic science’s importance for clinical practice.
Publish Date	2022-03-10 12:08
Citation	Currais P, Rosa I, Claro I. Colorectal cancer carcinogenesis: From bench to bedside. World J Gastrointest Oncol 2022; 14(3): 654-663
URL	https://www.wjgnet.com/1948-5204/full/v14/i3/654.htm
DOI	https://dx.doi.org/10.4251/wjgo.v14.i3.654

Full Article (PDF)	WJGO-14-654.pdf
Full Article (Word)	WJGO-14-654.docx
Manuscript File	71964_Auto_Edited-LLW-Wang TQ.docx
Answering Reviewers	71964-Answering reviewers.pdf
Audio Core Tip	71964-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	71964-Conflict-of-interest statement.pdf
Copyright License Agreement	71964-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	71964-Language certificate.pdf
Peer-review Report	71964-Peer-review(s).pdf
Scientific Misconduct Check	71964-Bing-Wang LL-2.png
Scientific Editor Work List	71964-Scientific editor work list.pdf