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Articles Published Processes
3/10/2022 12:08:49 PM | Browse: 401 | Download: 810
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Received |
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2021-09-27 22:31 |
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Peer-Review Started |
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2021-09-27 22:34 |
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To Make the First Decision |
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Return for Revision |
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2021-12-04 20:40 |
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Revised |
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2021-12-18 20:46 |
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Second Decision |
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2022-02-17 05:48 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-02-20 13:15 |
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Articles in Press |
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2022-02-20 13:15 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-01-22 12:42 |
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Typeset the Manuscript |
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2022-03-02 23:31 |
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Publish the Manuscript Online |
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2022-03-10 12:08 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Colorectal cancer carcinogenesis: From bench to bedside
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Pedro Currais, Isadora Rosa and Isabel Claro |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Isadora Rosa, PhD, Doctor, Doctor, Gastroenterology, Instituto Portugues de Oncologia de Lisboa Francisco Gentil, Rua Prof. Lima Basto, Lisboa 1099-023, Portugal. isarosa@ipolisboa.min-saude.pt |
| Key Words |
Colorectal cancer; Carcinogenesis pathways; Microsatellite instability; APC; KRAS; BRAF |
| Core Tip |
Colorectal cancer (CRC) is a major cause of cancer death worldwide. It is a heterogeneous entity and its molecular and genetic features have clinical implications. Three main carcinogenesis pathways, with some overlapping features, are now known to lead to CRC: Chromosomal instability, microsatellite instability, and the “serrated” pathways. Their features, namely, microsatellite instability status and BRAF or KRAS mutation status, among others, have to be studied to assess familial cancer risk and to make adequate therapy choices. Ongoing research will potentially even enlarge basic science’s importance for clinical practice. |
| Publish Date |
2022-03-10 12:08 |
| Citation |
Currais P, Rosa I, Claro I. Colorectal cancer carcinogenesis: From bench to bedside. World J Gastrointest Oncol 2022; 14(3): 654-663 |
| URL |
https://www.wjgnet.com/1948-5204/full/v14/i3/654.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v14.i3.654 |
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