Publication Name	World Journal of Gastroenterology
Manuscript ID	7200
Country	China

Received	2013-11-08 20:27
Peer-Review Started	2013-11-09 21:37
To Make the First Decision	2013-12-26 11:27
Return for Revision	2014-01-06 16:00
Revised
Second Decision	2014-03-19 13:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-03-19 15:22
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-04-17 12:03
Typeset the Manuscript	2014-05-14 09:07
Publish the Manuscript Online	2014-05-28 11:45

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Detection of promoter hypermethylation of Wnt antagonist genes in fecal samples for diagnosis of early colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Hu Zhang, You-Qing Zhu, Ya-Qiong Wu, Ping Zhang and Jian Qi
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81101868 Natural Science Foundation of Hubei Province of China 2011CDB505
Corresponding Author	Jian Qi, PhD, MD, Department of Gastroenterology and Clinical Center of Intestinal and Colorectal Diseases of Hubei Province, Zhongnan Hospital of Wuhan University, No. 169 Donghu Road, Wuchang District, Wuhan 430071, Hubei Province, China. qiqidelizl@aliyun.com
Key Words	Colorectal carcinoma; Secreted frizzled-related protein 2; Wnt inhibitory factor-1; Stool; Methylation
Core Tip	Currently available approaches for the early detection of colorectal carcinoma (CRC) are suboptimal. The analysis of methylation markers in the stool as a non-invasive test is important for the early diagnosis of CRC. The epigenetic silencing of Wnt antagonist genes occurs in the early stages of CRC, and up to 90% of colorectal cancers result in the aberrant activation of Wnt signaling. In our study, we found that hypermethylated SFRP2 and WIF-1 genes in fecal DNA are novel and promising molecular biomarkers that have a great potential for the diagnosis of early CRC.
Publish Date	2014-05-28 11:45
Citation	Zhang H, Zhu YQ, Wu YQ, Zhang P, Qi J. Detection of promoter hypermethylation of Wnt antagonist genes in fecal samples for diagnosis of early colorectal cancer. World J Gastroenterol 2014; 20(20): 6329-6335
URL	http://www.wjgnet.com/1007-9327/full/v20/i20/6329.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i20.6329

Full Article (PDF)	WJG-20-6329.pdf
Full Article (Word)	WJG-20-6329.doc
Manuscript File	7200-Review.doc
Answering Reviewers	7200-Peer reviewer(s).pdf
Copyright License Agreement	7200-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7200-Language certificate.pdf
Peer-review Report	7200-Peer reviewer(s).pdf
Scientific Editor Work List	7200-Scientific editor work list.doc