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9/7/2014 1:30:00 PM | Browse: 470 | Download: 218
Publication Name World Journal of Gastroenterology
Manuscript ID 7201
Country/Territory Spain
Received
2013-11-08 20:33
Peer-Review Started
2013-11-09 21:46
To Make the First Decision
2014-01-15 19:43
Return for Revision
2014-01-20 17:33
Revised
2014-01-23 22:49
Second Decision
2014-05-19 11:03
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-05-19 11:21
Articles in Press
2014-05-23 09:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-08-20 14:50
Publish the Manuscript Online
2014-09-07 13:31
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Retrospective Study
Article Title Non invasive blood flow measurement in cerebellum detects minimal hepatic encephalopathy earlier than psychometric tests
Manuscript Source Invited Manuscript
All Author List Vicente Felipo, Amparo Urios, Carla Giménez-Garzó, Omar Cauli, Maria-Jesús Andrés-Costa, Olga González, Miguel A Serra, Javier Sánchez-González, Roberto Aliaga, Remedios Giner-Durán, Vicente Belloch and Carmina Montoliu
Funding Agency and Grant Number
Funding Agency Grant Number
Ministerio de Ciencia e Innovación FIS PS09/00806
Ministerio de Ciencia e Innovación FIS PI12/00884 (to Montoliu C)
Ministerio de Ciencia e Innovación SAF2011-23051 (to Felipo V)
Ministerio de Ciencia e Innovación CSD2008-00005 (to Felipo V)
Consellería de Educación Generalitat Valenciana PROMETEO-2009-027 (to Felipo V)
Consellería de Educación Generalitat Valenciana ACOMP/2012/066 (to Felipo V)
Consellería de Educación Generalitat Valenciana ACOMP/2012/056 (to Montoliu C)
Sanitat AP-004/11 (to Felipo V)
Sanitat AP-087/11 to Montoliu C
Fundación ERESA to Montoliu C
Corresponding author Carmina Montoliu, PhD, Fundación Investigación Hospital Clínico de Valencia. Instituto de Investigación Sanitaria, INCLIVA, , Avda Blasco Ibañez, 17, 46010 Valencia, Spain. cmontoliu@incliva.es
Keywords Arterial spin labelling; Neurological impairment; Blood flow; Cerebellum; Minimal hepatic encephalopathy
Core Tip Patients with minimal hepatic encephalopathy (MHE) show neurological impairment in specific tasks to which selective regional alterations in blood flow (BF) could contribute. Arterial spin labeling (ASL), a non-invasive magnetic resonance technique, quantitatively measures cerebral perfusion. We analyzed BF by ASL in different brain areas of controls and cirrhotic patients without and with MHE. We found that BF is more affected in cerebellum than in other areas of cirrhotic patients and that BF determination in cerebellum using ASL may detect MHE earlier than the Psychometric Hepatic Encephalopathy Score battery. Altered nitric oxide-cGMP pathway seems to be associated to altered BF in cerebellum.
Publish Date 2014-09-07 13:31
Citation Felipo V, Urios A, Giménez-Garzó C, Cauli O, Andrés-Costa MJ, González O, Serra MA, Sánchez-González J, Aliaga R, Giner-Durán R, Belloch V, Montoliu C. Non invasive blood flow measurement in cerebellum detects minimal hepatic encephalopathy earlier than psychometric tests. World J Gastroenterol 2014; 20(33): 11815-11825
Url http://www.wjgnet.com/1007-9327/full/v20/i33/11815.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i33.11815
Full Article (PDF) WJG-20-11815.pdf
Full Article (Word) WJG-20-11815.doc
Manuscript File 7201-Review.doc
Answering Reviewers 7201-Answeing reviewers.pdf
Copyright License Agreement 7201-Copyright assignment.pdf
Peer-review Report 7201-Peer reviewer(s).pdf
Scientific Editor Work List 7201-Scientific editor work list.pdf