| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Non invasive blood flow measurement in cerebellum detects minimal hepatic encephalopathy earlier than psychometric tests
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Vicente Felipo, Amparo Urios, Carla Giménez-Garzó, Omar Cauli, Maria-Jesús Andrés-Costa, Olga González, Miguel A Serra, Javier Sánchez-González, Roberto Aliaga, Remedios Giner-Durán, Vicente Belloch and Carmina Montoliu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ministerio de Ciencia e Innovación |
FIS PS09/00806 |
| Ministerio de Ciencia e Innovación |
FIS PI12/00884 (to Montoliu C) |
| Ministerio de Ciencia e Innovación |
SAF2011-23051 (to Felipo V) |
| Ministerio de Ciencia e Innovación |
CSD2008-00005 (to Felipo V) |
| Consellería de Educación Generalitat Valenciana |
PROMETEO-2009-027 (to Felipo V) |
| Consellería de Educación Generalitat Valenciana |
ACOMP/2012/066 (to Felipo V) |
| Consellería de Educación Generalitat Valenciana |
ACOMP/2012/056 (to Montoliu C) |
| Sanitat |
AP-004/11 (to Felipo V) |
| Sanitat |
AP-087/11 to Montoliu C |
| Fundación ERESA |
to Montoliu C |
|
| Corresponding Author |
Carmina Montoliu, PhD, Fundación Investigación Hospital Clínico de Valencia. Instituto de Investigación Sanitaria, INCLIVA, , Avda Blasco Ibañez, 17, 46010 Valencia, Spain. cmontoliu@incliva.es |
| Key Words |
Arterial spin labelling; Neurological impairment; Blood flow; Cerebellum; Minimal hepatic encephalopathy |
| Core Tip |
Patients with minimal hepatic encephalopathy (MHE) show neurological impairment in specific tasks to which selective regional alterations in blood flow (BF) could contribute. Arterial spin labeling (ASL), a non-invasive magnetic resonance technique, quantitatively measures cerebral perfusion. We analyzed BF by ASL in different brain areas of controls and cirrhotic patients without and with MHE. We found that BF is more affected in cerebellum than in other areas of cirrhotic patients and that BF determination in cerebellum using ASL may detect MHE earlier than the Psychometric Hepatic Encephalopathy Score battery. Altered nitric oxide-cGMP pathway seems to be associated to altered BF in cerebellum. |
| Publish Date |
2014-09-07 13:31 |
| Citation |
Felipo V, Urios A, Giménez-Garzó C, Cauli O, Andrés-Costa MJ, González O, Serra MA, Sánchez-González J, Aliaga R, Giner-Durán R, Belloch V, Montoliu C. Non invasive blood flow measurement in cerebellum detects minimal hepatic encephalopathy earlier than psychometric tests. World J Gastroenterol 2014; 20(33): 11815-11825 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i33/11815.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i33.11815 |
