Publication Name	World Journal of Hepatology
Manuscript ID	7205
Country	Italy

Received	2013-11-08 20:50
Peer-Review Started	2013-11-10 14:38
To Make the First Decision	2014-01-16 08:31
Return for Revision	2014-03-04 09:08
Revised	2014-03-19 01:38
Second Decision	2014-05-29 15:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-29 15:57
Articles in Press	2014-05-29 15:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-22 17:20
Publish the Manuscript Online	2014-07-25 16:43

ISSN	1948-5182 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Parasitology
Manuscript Type	Review
Article Title	Juvenile autoimmune hepatitis: Spectrum of the disease
Manuscript Source	Invited Manuscript
All Author List	Giuseppe Maggiore, Silvia Nastasio and Marco Sciveres
Funding Agency and Grant Number
Corresponding Author	Giuseppe Maggiore, MD, Department of Clinical and Experimental Medicine, Pediatric Gastroenterology, University Hospital of Pisa, Via Roma 67, 56127 Pisa, Italy. giuseppe.maggiore@med.unipi.it
Key Words	Juvenile autoimmune hepatitis; Autoimmune hepatitis; Autoantibodies; Autoimmune liver disease; Chronic hepatitis; Acute liver failure
Core Tip	Juvenile autoimmune hepatitis is an inflammatory liver disease affecting mainly young girls from infancy to late adolescence, characterized by active liver damage, elevated immunoglobulin G levels, high titers of serum non organ-specific and organ-specific autoantibodies, and interface hepatitis on liver biopsy. Two types are identified according to the autoantibody panel, with differences in the epidemiological distribution, genetic markers and clinical presentation. The most effective therapy for autoimmune hepatitis is pharmacological suppression of the immune response. Treatment should be started as soon as the diagnosis is made to avoid severe liver damage and progression of fibrosis.
Publish Date	2014-07-25 16:43
Citation	Maggiore G, Nastasio S, Sciveres M. Juvenile autoimmune hepatitis: Spectrum of the disease. World J Hepatol 2014; 6(7): 464-476
URL	http://www.wjgnet.com/1948-5182/full/v6/i7/464.htm
DOI	http://dx.doi.org/10.4254/wjh.v6.i7.464

Full Article (PDF)	WJH-6-464.pdf
Full Article (Word)	WJH-6-464.doc
Manuscript File	7205-Review.doc
Answering Reviewers	7205-Answering reviewers.pdf
Copyright License Agreement	7205-Copyright assignment.PDF
Peer-review Report	7205-Peer review(s).pdf
Scientific Misconduct Check	7205-CrossCheck.jpg
Scientific Editor Work List	7205-Scientific editor work list.pdf