Publication Name	World Journal of Gastroenterology
Manuscript ID	7218
Country	China

Received	2013-11-09 10:33
Peer-Review Started	2013-11-09 21:06
To Make the First Decision	2013-12-16 18:09
Return for Revision	2013-12-20 23:40
Revised	2014-02-08 20:29
Second Decision	2014-03-19 13:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-03-19 15:21
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-04-18 17:43
Typeset the Manuscript	2014-04-25 17:23
Publish the Manuscript Online	2014-05-14 10:58

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Expression of Bmi-1 and PAI-1 in esophageal squamous cell carcinoma
Manuscript Source	Invited Manuscript
All Author List	Yan Zhang, Ya-Lou Zhang, Hong-Ming Chen, Hong-Wei Pu, Wen-Jing Ma, Xiao-Mei Li, Hong Ma and Xiao Chen
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Xinjiang Uygur Autonomous Region 2012211A035 Graduate Research and Innovation Project of Xnjiang Uygur Autonomous Region XJGRI2013076 Research and Innovation Project of Xinjiang Medical University XJC201314
Corresponding Author	Xiao Chen, PhD, Professor, Department of Pathology, Xinjiang Medical University, No. 339 Xin Yi Road, Urumqi 830011, Xinjiang Uygur Autonomous Region, China. xjchenxiao@sina.com
Key Words	Esophageal squamous cell carcinoma; B-cell-specific moloney leukemia virus insert site 1; Plasminogen activator inhibitor-1; Metastasis; Prognosis
Core Tip	In this study, B-cell-specific Moloney leukemia virus insert site 1 (Bmi-1) and plasminogen activator inhibitor-1 (PAI-1) expression, their correlation with clinicopathological features, and their prognostic significance in esophageal squamous cell carcinoma (ESCC) were examined. The results showed that the Bmi-1 protein promoted malignant transformation, increased invasion and metastasis of cells. PAI-1 was not an independent prognostic factor. Although these new markers are important, the molecular mechanism of ESCC metastasis is far from being fully understood and represents a new prerequisite for developing better treatment strategies.
Publish Date	2014-05-14 10:58
Citation	Zhang Y, Zhang YL, Chen HM, Pu HW, Ma WJ, Li XM, Ma H, Chen X. Expression of Bmi-1 and PAI-1 in esophageal squamous cell carcinoma. World J Gastroenterol 2014; 20(18): 5533-5539
URL	http://www.wjgnet.com/1007-9327/full/v20/i18/5533.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i18.5533

Full Article (PDF)	WJG-20-5533.pdf
Full Article (Word)	WJG-20-5533.doc
Manuscript File	7218-Review.doc
Answering Reviewers	7218-Answering reviewers.pdf
Copyright License Agreement	7218-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20131108160148.pdf
Non-Native Speakers of English Editing Certificate	7218-Language certificate.pdf
Peer-review Report	7218-Peer reviewer(s).pdf
Scientific Editor Work List	7218-Scientific editor work list.doc