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1/21/2022 8:16:14 AM | Browse: 274 | Download: 473
Publication Name World Journal of Hepatology
Manuscript ID 72226
Country United States
Received
2021-10-08 20:23
Peer-Review Started
2021-10-08 20:24
To Make the First Decision
Return for Revision
2021-11-17 08:03
Revised
2021-11-23 19:59
Second Decision
2021-12-29 03:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-12-31 22:22
Articles in Press
2021-12-31 22:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-01-18 04:30
Publish the Manuscript Online
2022-01-21 08:16
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Transplantation
Manuscript Type Case Report
Article Title Acute liver failure secondary to acute antibody mediated rejection after compatible liver transplant: A case report
Manuscript Source Unsolicited Manuscript
All Author List Todd J Robinson, James B Hendele, Idoia Gimferrer, Nicolae Leca, Scott W Biggins, Jorge D Reyes and Lena Sibulesky
ORCID
Author(s) ORCID Number
Todd J Robinson http://orcid.org/0000-0001-5230-8435
James B Hendele http://orcid.org/0000-0003-1477-9003
Idoia Gimferrer http://orcid.org/0000-0002-5535-352X
Nicolae Leca http://orcid.org/0000-0003-3279-2930
Scott W Biggins http://orcid.org/0000-0002-3081-4668
Jorge D Reyes http://orcid.org/0000-0003-3065-8674
Lena Sibulesky http://orcid.org/0000-0001-5435-737X
Funding Agency and Grant Number
Corresponding Author Lena Sibulesky, MD, Associate Professor, Surgeon, Department of Surgery, University of Washington Medical Center, UWMC 1959 NE Pacific St, Box 356410 Seattle, Seattle, WA 98195, United States. lenasi@uw.edu
Key Words Liver transplant; Acute antibody mediated rejection; Acute liver failure; Donor specific antibody; Liver rejection; Case report
Core Tip The liver has traditionally been regarded as resistant to antibody-mediated rejection (AMR). AMR in liver transplants is a field in its infancy compared to kidney and lung transplants. We present a case of a 56 year-old woman with alpha-1-antitrypsin disease who underwent ABO compatible liver transplant. The flow cytometric crossmatches were noted to be positive for T and B lymphocytes. After initial posttransplant recovery she progressively developed acute liver failure with evidence of antibody mediated rejection with portal inflammation, bile duct injury, endothelitis, and extensive centrizonal necrosis, and C4d staining on allograft biopsy and elevated donor-specific antibodies. Despite various interventions including plasmapheresis and immunomodulating therapy, she required retranpslantation.
Publish Date 2022-01-21 08:16
Citation Robinson TJ, Hendele JB, Gimferrer I, Leca N, Biggins SW, Reyes JD, Sibulesky L. Acute liver failure secondary to acute antibody mediated rejection after compatible liver transplant: A case report. World J Hepatol 2022; 14(1): 287-294
URL https://www.wjgnet.com/1948-5182/full/v14/i1/287.htm
DOI https://dx.doi.org/10.4254/wjh.v14.i1.287
Full Article (PDF) WJH-14-287.pdf
Full Article (Word) WJH-14-287.docx
Manuscript File 72226_Auto_Edited.docx
Answering Reviewers 72226-Answering reviewers.pdf
Audio Core Tip 72226-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 72226-Conflict-of-interest statement.pdf
Copyright License Agreement 72226-Copyright license agreement.pdf
Signed Consent for Treatment Form(s) or Document(s) 72226-Informed consent statement.pdf
Peer-review Report 72226-Peer-review(s).pdf
Scientific Misconduct Check 72226-Bing-Fan JR-2.png
Scientific Editor Work List 72226-Scientific editor work list.pdf