Publication Name	World Journal of Cardiology
Manuscript ID	7225
Country	Switzerland

Received	2013-11-09 11:03
Peer-Review Started	2013-11-09 19:33
To Make the First Decision	2013-12-25 18:19
Return for Revision	2014-03-24 18:49
Revised	2014-03-24 23:32
Second Decision	2014-04-11 18:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-11 19:09
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-05-28 09:29
Publish the Manuscript Online	2014-06-20 19:33

ISSN	1949-8462 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Topic Highlights
Article Title	Potential pathophysiological role for the vitamin D deficiency in essential hypertension
Manuscript Source	Invited Manuscript
All Author List	Federico Carbone, François Mach, Nicolas Vuilleumier and Fabrizio Montecucco
Funding Agency and Grant Number	Funding Agency Grant Number European Commission (FP7-INNOVATION I HEALTH-F2-2013-602114; Athero-B-Cell: Targeting and exploiting B cell function for treatment in cardiovascular disease) to Dr. F Mach Swiss National Science Foundation #310030_118245 (to Dr. F Mach) Swiss National Science Foundation #310030_140736 (to Dr. N Vuilleumier) Swiss National Science Foundation #32003B_134963/1 (to Dr. F Montecucco) Novartis Foundation and the Foundation “Gustave and Simone Prévot” to Dr. F Montecucco
Corresponding Author	Dr. Fabrizio Montecucco, MD, PhD, Division of Laboratory Medicine, Department of Genetics and Laboratory Medicine, Geneva University Hospitals, 4 rue Gabrielle-Perret-Gentil, 1205 Geneva, Switzerland. fabrizio.montecucco@unige.ch
Key Words	Vitamin D; Hypertension; Cardiovascular disease; Renin; Angiotensin
Core Tip	This review provides a comprehensive and critical analysis of the most recent studies investigating the relationship between vitamin D and essential hypertension. From the both observational and interventional studies, conflicting results have been shown. This review article provides some hypothesis to explain these discrepancies. In addition to the potential bias related to the study design, some pathophysiological explanation was suggested, especially involving the potential role of local vitamin D system as well as the fibroblast growth factor 23/klotho axis. This review aims at suggesting a careful reflection so that future studies might be designed for minimize bias and encompass the complex biology of vitamin D system.
Publish Date	2014-06-20 19:33
Citation	Carbone F, Mach F, Vuilleumier N, Montecucco F. Potential pathophysiological role for the vitamin D deficiency in essential hypertension. World J Cardiol 2014; 6(5): 260-276
URL	http://www.wjgnet.com/1949-8462/full/v6/i5/260.htm
DOI	http://dx.doi.org/10.4330/wjc.v6.i5.260

Full Article (PDF)	WJC-6-260.pdf
Full Article (Word)	WJC-6-260.doc
Manuscript File	7225-Review.doc
Answering Reviewers	7225-Answering reviewers.pdf
Copyright License Agreement	7225-Copyright assignment.pdf
Peer-review Report	7225-Peer review(s).pdf
Scientific Editor Work List	7225-Scientific editor work list.doc