Publication Name	World Journal of Gastroenterology
Manuscript ID	723
Country	Poland

Received	2012-10-05 05:21
Peer-Review Started	2012-10-07 16:58
To Make the First Decision	2013-01-05 15:47
Return for Revision	2013-01-05 16:53
Revised	2013-02-06 01:28
Second Decision	2013-03-06 17:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-03-07 06:59
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-07-09 13:45
Publish the Manuscript Online	2013-07-20 20:47

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Gastrointestinal side effects in children with Wilson's disease treated with zinc sulphate
Manuscript Source	Invited Manuscript
All Author List	Anna Wiernicka, Wojciech Jańczyk, Maciej Dądalski, Yesim Avsar, Hartmut Schmidt and Piotr Socha
Funding Agency and Grant Number
Corresponding Author	Piotr Socha, Professor, Department of Gastroenterology, Hepatology and Malnutrition, the Children’s Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland. p.socha@czd.pl
Key Words	Wilson’s disease; Zinc; Abdominal pain; Gastrointestinal ulcer; Therapy
Core Tip	The present study demonstrates a considerably higher rate and severity of gastrointestinal adverse effects secondary to zinc sulphate therapy in pediatric patients as previously reported. A total of 40% of our treated patients experienced gastrointestinal symptoms, of which the more severe cases were associated with endoscopically evident gastric ulcerations and erosions. Furthermore it was shown, that proton pump inhibitors were not effective in treating patients with severe zinc associated gastrointestinal side effects, requiring a switch to an alternative treatment regimen.
Publish Date	2013-07-20 20:47
Citation	Wiernicka A, Jańczyk W, Dądalski M, Avsar Y, Schmidt H, Socha P. Gastrointestinal side effects in children with Wilson’s disease treated with zinc sulphate. World J Gastroenterol 2013; 19(27): 4356-4362
URL	http://www.wjgnet.com/1007-9327/full/v19/i27/4356.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i27.4356

Full Article (PDF)	WJG-19-4356.pdf
Manuscript File	723-Review.docx
Answering Reviewers	723-Answering reviewers.pdf
Copyright License Agreement	723-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	723-Language certificate.PDF
Peer-review Report	723-Peer reviews.docx
Scientific Editor Work List	723-Scientific editor work list.doc