Publication Name	World Journal of Clinical Cases
Manuscript ID	72345
Country	China

Received	2021-10-12 13:53
Peer-Review Started	2021-10-12 13:54
To Make the First Decision
Return for Revision	2021-12-04 08:28
Revised	2021-12-12 11:01
Second Decision	2022-02-24 06:10
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-02-27 19:40
Articles in Press	2022-02-27 19:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-03-04 22:40
Publish the Manuscript Online	2022-03-22 14:34

ISSN	2307-8960 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Role of metabolites derived from gut microbiota in inflammatory bowel disease
Manuscript Source	Invited Manuscript
All Author List	Lie Zheng, Xin-Li Wen and Sheng-Lei Duan
ORCID	Author(s) ORCID Number Lie Zheng http://orcid.org/0000-0002-8243-3736 Xin-Li Wen http://orcid.org/0000-0001-5003-862X Sheng-Lei Duan http://orcid.org/0000-0002-4151-1718
Funding Agency and Grant Number
Corresponding Author	Xin-Li Wen, MD, Chief Doctor, Department of Gastroenterology, Department of Gastroenterology,, Department of Gastroenterology, xian 730000, China. xinliwen696@126.com
Key Words	Inflammatory bowel disease; Microbial metabolites; Short chain fatty acids; Bile acids; Tryptophan
Core Tip	In the gastrointestinal tract of the human, a variety of microorganisms such as bacteria, fungi, viruses, archaea and protozoa are collected and considered as a community, containing a genome, suitable to the environment and the host. Microbiome, with wide functions, can ferment dietary fibres, defence pathogen, synthesize vitamin and promote immune maturation and metabolic homeostasis, which indicates microbiome is deeply integrated with human biology. However, because gut microbiota is associated with ancestral diet high in fibre, the dietary alteration resulted from western diet causes maladaptive change for this association, and products of microbial metabolism exist at a nexus between host and microbiome.
Publish Date	2022-03-22 14:34
Citation	Zheng L, Wen XL, Duan SL. Role of metabolites derived from gut microbiota in inflammatory bowel disease. World J Clin Cases 2022; 10(9): 2660-2677
URL	https://www.wjgnet.com/2307-8960/full/v10/i9/2660.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i9.2660

Full Article (PDF)	WJCC-10-2660.pdf
Full Article (Word)	WJCC-10-2660.docx
Manuscript File	72345_Auto_Edited-LJH.docx
Answering Reviewers	72345-Answering reviewers.pdf
Audio Core Tip	72345-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	72345-Conflict-of-interest statement.pdf
Copyright License Agreement	72345-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	72345-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	72345-Language certificate.pdf
Peer-review Report	72345-Peer-review(s).pdf
Scientific Misconduct Check	72345-CrossCheck.jpg
Scientific Misconduct Check	72345-Bing-Liu JH-2.jpg
Scientific Editor Work List	72345-Scientific editor work list.pdf
CrossCheck Report	72345-CrossCheck report.pdf