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Articles Published Processes
2/25/2022 12:19:16 PM | Browse: 455 | Download: 1044
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Received |
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2021-10-13 15:33 |
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Peer-Review Started |
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2021-10-13 15:34 |
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To Make the First Decision |
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Return for Revision |
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2021-11-08 03:17 |
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Revised |
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2021-11-29 14:36 |
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Second Decision |
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2022-01-24 03:54 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-01-25 03:18 |
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Articles in Press |
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2022-01-25 03:18 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-02-22 01:42 |
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Publish the Manuscript Online |
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2022-02-25 12:19 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
Extracellular vesicles from hypoxia-preconditioned mesenchymal stem cells alleviates myocardial injury by targeting thioredoxin-interacting protein-mediated hypoxia-inducible factor-1α pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Cheng-Yu Mao, Tian-Tian Zhang, Dong-Jiu Li, En Zhou, Yu-Qi Fan, Qing He, Chang-Qian Wang and Jun-Feng Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81870264 |
| National Natural Science Foundation of China |
81470546 |
| the Shanghai Committee of Science and Technology |
18411950500 |
| the Major Disease Joint Project of Shanghai Health System |
2014ZYJB0501 |
| Talent Cultivation Project of The Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine |
JC202005 |
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| Corresponding Author |
Jun-Feng Zhang, MD, PhD, Professor, Department of Cardiology, Shanghai Ninth People’s Hospital affiliated to Shanghai Jiao Tong University School of Medicine, No. 280 Mohe Road, Baoshan District, Shanghai 200010, China. junfengzhang9hos@163.com |
| Key Words |
Extracellular vesicles; Myocardial infarction; Mesenchymal stem cells; Hypoxia preconditioning; Thioredoxin-interacting protein; Hypoxia-inducible factor 1 alpha |
| Core Tip |
Extracellular vesicles (EVs) from adipose-derived mesenchymal stem cells treated with hypoxia preconditioning improve tolerance toward myocardial infarction or hypoxic conditions and alleviate the degree of cardiomyocyte apoptosis until reperfusion therapy. The anti-apoptotic effects may result from EV miR-224-5p targeting thioredoxin-interacting protein (TXNIP) and subsequent TXNIP-mediated hypoxia-inducible factor-1 alpha ubiquitination and degradation via the chromosomal region maintenance-1-mediated nuclear transport pathway. |
| Publish Date |
2022-02-25 12:19 |
| Citation |
Mao CY, Zhang TT, Li DJ, Zhou E, Fan YQ, He Q, Wang CQ, Zhang JF. Extracellular vesicles from hypoxia-preconditioned mesenchymal stem cells alleviates myocardial injury by targeting thioredoxin-interacting protein-mediated hypoxia-inducible factor-1α pathway. World J Stem Cells 2022; 14(2): 183-199 |
| URL |
https://www.wjgnet.com/1948-0210/full/v14/i2/183.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v14.i2.183 |
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