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Articles Published Processes
3/22/2022 2:34:59 PM | Browse: 402 | Download: 1447
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Received |
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2021-10-14 11:37 |
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Peer-Review Started |
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2021-10-14 11:41 |
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To Make the First Decision |
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Return for Revision |
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2021-12-13 18:10 |
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Revised |
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2021-12-20 20:09 |
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Second Decision |
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2022-02-11 05:50 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-02-13 16:48 |
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Articles in Press |
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2022-02-13 16:48 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-03-04 22:41 |
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Publish the Manuscript Online |
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2022-03-22 14:34 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Animal models applied to acute-on-chronic liver failure: Are new models required to understand the human condition?
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jaciara Fernanda Gomes Gama, Liana Monteiro da Fonseca Cardoso, Jussara Machado Lagrota-Candido and Luiz Anastacio Alves |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro |
001 |
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| Corresponding Author |
Luiz Anastacio Alves, MD, PhD, Academic Research, Professor, Research Scientist, Laboratory of Cellular Communication, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Av. Brazil, 4365 Manguinhos., Rio de Janeiro 21045900, Rio de Janeiro, Brazil. alveslaa@gmail.com |
| Key Words |
Liver disease; Acute-on-chronic liver failure; Cirrhosis; Acute decompensate event; Translational study; Animal models |
| Core Tip |
The liver is a multifaceted organ; its location and detoxifying function expose it to countless injuries. Acute-on-chronic failure liver (ACLF) is a severe syndrome that affects the liver due to acute decompensation in patients with chronic liver disease. Animal models become a very useful tool in this regard. However, although they display several similarities to the human condition, they do not represent all manifestations, resulting in significant challenges. A quick PubMed database search indicates about 30 studies concerning ACLF models. These findings demonstrate the need to establish easily reproducible models to elucidate questions about this quickly established and often fatal syndrome. |
| Publish Date |
2022-03-22 14:34 |
| Citation |
Gama JFG, Cardoso LMDF, Lagrota-Candido JM, Alves LA. Animal models applied to acute-on-chronic liver failure: Are new models required to understand the human condition? World J Clin Cases 2022; 10(9): 2687-2699 |
| URL |
https://www.wjgnet.com/2307-8960/full/v10/i9/2687.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v10.i9.2687 |
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