Publication Name	World Journal of Gastroenterology
Manuscript ID	72396
Country	Türkiye

Received	2021-10-14 17:23
Peer-Review Started	2021-10-14 17:24
To Make the First Decision
Return for Revision	2021-12-03 20:40
Revised	2021-12-15 01:45
Second Decision	2022-01-21 05:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-01-22 20:36
Articles in Press	2022-01-22 20:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-02-14 09:39
Publish the Manuscript Online	2022-02-24 09:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Pathology
Manuscript Type	Minireviews
Article Title	Mixed neuroendocrine–nonneuroendocrine neoplasms of the gastrointestinal system: An update
Manuscript Source	Invited Manuscript
All Author List	Gulsum Ozlem Elpek
ORCID	Author(s) ORCID Number Gulsum Ozlem Elpek http://orcid.org/0000-0002-1237-5454
Funding Agency and Grant Number
Corresponding Author	Gulsum Ozlem Elpek, MD, Professor, Pathology , Akdeniz University Medical School, Dumlupınar bulvarı, Antalya 07070, Türkiye. elpek@akdeniz.edu.tr
Key Words	Mixed neuroendocrine–nonneuroendocrine neoplasms; Mixed adeno neuroendocrine carcinoma; Gastrointestinal system; Liver; Pancreas; Gallbladder
Core Tip	Mixed neuroendocrine-nonneuroendocrine neoplasms of the gastrointestinal system are a rare heterogeneous group of tumors that present many challenges in terms of diagnosis and treatment. Current data indicate that they are more frequent in the colon and rectum and that most of them consist of aggressive tumors that have poor prognoses in older men. Their correct diagnosis with the proposed criteria and the separate assessment of the grade of each component are crucial in terms of determining the treatment. Although studies have indicated a monoclonal origin, further studies are needed to determine whether these molecular changes could become treatment targets.
Publish Date	2022-02-24 09:46
Citation	Elpek GO. Mixed neuroendocrine–nonneuroendocrine neoplasms of the gastrointestinal system: An update. World J Gastroenterol 2022; 28(8): 794-810
URL	https://www.wjgnet.com/1007-9327/full/v28/i8/794.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i8.794

Full Article (PDF)	WJG-28-794.pdf
Full Article (Word)	WJG-28-794.docx
Manuscript File	72396_Auto_Edited-YJM.docx
Answering Reviewers	72396-Answering reviewers.pdf
Audio Core Tip	72396-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	72396-Conflict-of-interest statement.pdf
Copyright License Agreement	72396-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	72396-Language certificate.pdf
Peer-review Report	72396-Peer-review(s).pdf
Scientific Editor Work List	72396-Scientific editor work list.pdf
CrossCheck Report	72396-CrossCheck report.pdf