Publication Name	World Journal of Gastroenterology
Manuscript ID	7252
Country	China

Received	2013-11-11 09:51
Peer-Review Started	2013-11-13 12:17
To Make the First Decision	2013-12-16 18:08
Return for Revision	2013-12-20 23:37
Revised	2014-03-16 14:52
Second Decision	2014-06-23 10:03
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-23 10:24
Articles in Press	2014-06-23 10:35
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-07-05 10:43
Typeset the Manuscript	2014-10-10 17:29
Publish the Manuscript Online	2014-10-20 18:35

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Evaluation of “top-down” treatment of early Crohn’s disease by double balloon enteroscopy
Manuscript Source	Invited Manuscript
All Author List	Rong Fan, Jie Zhong, Zheng-Ting Wang, Shu-Yi Li, Jie Zhou and Yong-Hua Tang
Funding Agency and Grant Number
Corresponding Author	Jie Zhong, MD, PhD, Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Er Road, Shanghai 200025, China. jimmyzj64@medmail.com.cn
Key Words	Crohn’s disease; Top-down treatment; Deep remission; Double balloon enteroscopy; Mucosal healing
Core Tip	We assessed the outcome of “top-down” treatment in terms of deep remission in treatment-na?ve patients with early Crohn’s disease (CD) with small bowel involvement. This study is believed to be the first designed with deep remission as the primary endpoint. Furthermore, mucosal healing was assessed by double balloon enteroscopy for the first time in patients with CD treated with biologic agents. We excluded patients with luminal fibrostenotic or abdominal fistulizing CD in screening, resulting in encouraging deep remission rates at week 30. These results may have implications in the treatment of CD.
Publish Date	2014-10-20 18:35
Citation	Fan R, Zhong J, Wang ZT, Li SY, Zhou J, Tang YH. Evaluation of “top-down” treatment of early Crohn’s disease by double balloon enteroscopy. World J Gastroenterol 2014; 20(39): 14479-14487
URL	http://www.wjgnet.com/1007-9327/full/v20/i39/14479.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i39.14479

Full Article (PDF)	WJG-20-14479.pdf
Full Article (Word)	WJG-20-14479.doc
Manuscript File	7252-Review.doc
Answering Reviewers	7252-Answering reviewers.pdf
Copyright License Agreement	7252-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7252-Language certificate.pdf
Peer-review Report	7252-Peer review.pdf
Scientific Misconduct Check	7252-CorssCheck.jpg
Scientific Editor Work List	7252-Scientific editor work list.pdf