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Articles Published Processes
6/2/2022 10:05:35 AM | Browse: 627 | Download: 1938
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Received |
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2021-10-22 02:02 |
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Peer-Review Started |
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2021-10-22 02:04 |
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First Decision by Editorial Office Director |
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2021-12-27 04:50 |
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Return for Revision |
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2021-12-27 11:45 |
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Revised |
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2021-12-29 10:04 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2022-03-11 06:06 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2022-03-16 15:26 |
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Articles in Press |
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2022-03-16 15:26 |
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Edit the Manuscript by Language Editor |
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2022-03-09 10:33 |
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Typeset the Manuscript |
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2022-05-18 03:52 |
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Publish the Manuscript Online |
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2022-06-02 10:05 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Circulating miR-627-5p and miR-199a-5p are promising diagnostic biomarkers of colorectal neoplasia
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Dong-Yan Zhao, Lei Zhou, Teng-Fei Yin, Yuan-Chen Zhou, Ge-Yu-Jia Zhou, Qian-Qian Wang and Shu-Kun Yao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Development Plan for Precision Medicine Research |
No. 2017YFC0910002 |
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| Corresponding Author |
Shu-Kun Yao, PhD, Professor, Department of Gastroenterology, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing 100029, China. shukunyao@126.com |
| Key Words |
miR-627-5p; miR-199a-5p; Colorectal neoplasm; Biomarker; Screening; Serum |
| Core Tip |
This report is the first on the diagnostic usefulness of circulating miR-627-5p and miR-199a-5p in patients with colorectal neoplasms. We identified that serum levels of miR-627-5p and miR-199a-5p were markedly elevated in patients with colorectal neoplasia and appeared to be novel biomarkers for the non-invasive screening of colorectal neoplasia. An integrated model combining miR-199a-5p and miR-627-5p obtained a better discriminative capacity than each miRNA alone. Additionally, miR-627-5p and miR-199a-5p had different expression levels in the serum of cancer patients before and after surgery and in vitro gain-of-function experiments demonstrated that both microRNAs played crucial roles in regulating the progression and invasion of colorectal cancer cells. |
| Publish Date |
2022-06-02 10:05 |
| Citation |
Zhao DY, Zhou L, Yin TF, Zhou YC, Zhou GYJ, Wang QQ, Yao SK. Circulating miR-627-5p and miR-199a-5p are promising diagnostic biomarkers of colorectal neoplasia. World J Clin Cases 2022; 10(16): 5165-5184 |
| URL |
https://www.wjgnet.com/2307-8960/full/v10/i16/5165.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v10.i16.5165 |
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