Publication Name	World Journal of Gastroenterology
Manuscript ID	7253
Country	Saudi Arabia

Received	2013-11-11 09:54
Peer-Review Started	2013-11-13 12:15
To Make the First Decision	2013-12-26 11:25
Return for Revision	2014-01-06 16:43
Revised	2014-02-23 00:00
Second Decision	2014-06-23 10:04
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-06-23 10:24
Articles in Press	2014-06-23 10:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-12-17 17:39
Publish the Manuscript Online	2015-01-06 09:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Increased expression of tumor necrosis factor-a is associated with advanced colorectal cancer stages
Manuscript Source	Invited Manuscript
All Author List	Omar A Al Obeed, Khayal A Alkhayal, Abdulmalik Al Sheikh, Ahmad M Zubaidi, Mansoor-Ali Vaali-Mohammed, Robin Boushey, James H Mckerrow and Maha-Hamadien Abdulla
Funding Agency and Grant Number
Corresponding Author	Maha-Hamadien Abdulla, PhD, Assistant Professor, Director of Colorectal Research Center, Department of Surgery, King Khalid University Hospital, King Saud University, PO Box 7805(37), Riyadh 11472, Saudi Arabia. mabdulla@ksu.edu.sa
Key Words	Tumor necrosis factor-; Colorectal cancer; Real time polymerase chain reaction; Immunohistochemistry; mRNA
Core Tip	The relative expression of tumor necrosis factor-? (TNF-?) mRNA in colorectal cancer tumor tissue was significantly higher than adjacent normal tissue. In addition, higher TNF-? gene expression was associated significantly with advanced tumor as compared to early tumor stages. Colorectal tumor tissue contained many TNF-? positive cells, whereas normal colorectal tissue contained very few positive cells. We showed elevated TNF-? gene expression by cancer cells, which correlated strongly with advanced tumor stages. High levels of TNF-? expression could be an independent prognostic indicator, and targeting TNF-? may be a promising tool, which can be used to follow-up patients with colorectal carcinoma.
Publish Date	2015-01-06 09:08
Citation	Al Obeed OA, Alkhayal KA, Al Sheikh A, Zubaidi AM, Vaali-Mohammed MA, Boushey R, Mckerrow JH, Abdulla MH. Increased expression of tumor necrosis factor-a is associated with advanced colorectal cancer stages. World J Gastroenterol 2014; 20(48): 18390-18396
URL	http://www.wjgnet.com/1007-9327/full/v20/i48/18390.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i48.18390

Full Article (PDF)	WJG-20-18390.pdf
Full Article (Word)	WJG-20-18390.doc
Manuscript File	7253-Review.doc
Answering Reviewers	7253-Answering reviewers.pdf
Copyright License Agreement	7253-Copyright assignment.pdf
Peer-review Report	7253-Peer reviewer(s).pdf
Scientific Misconduct Check	7253-CorssCheck.jpg
Scientific Editor Work List	7253-Scientific editor work list.pdf