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1/6/2015 9:08:00 AM | Browse: 1182 | Download: 935
Publication Name World Journal of Gastroenterology
Manuscript ID 7253
Country/Territory Saudi Arabia
Received
2013-11-11 09:54
Peer-Review Started
2013-11-13 12:15
To Make the First Decision
2013-12-26 11:25
Return for Revision
2014-01-06 16:43
Revised
2014-02-23 00:00
Second Decision
2014-06-23 10:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-06-23 10:24
Articles in Press
2014-06-23 10:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-12-17 17:39
Publish the Manuscript Online
2015-01-06 09:08
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Retrospective Study
Article Title Increased expression of tumor necrosis factor-a is associated with advanced colorectal cancer stages
Manuscript Source Invited Manuscript
All Author List Omar A Al Obeed, Khayal A Alkhayal, Abdulmalik Al Sheikh, Ahmad M Zubaidi, Mansoor-Ali Vaali-Mohammed, Robin Boushey, James H Mckerrow and Maha-Hamadien Abdulla
Funding Agency and Grant Number
Corresponding Author Maha-Hamadien Abdulla, PhD, Assistant Professor, Director of Colorectal Research Center, Department of Surgery, King Khalid University Hospital, King Saud University, PO Box 7805(37), Riyadh 11472, Saudi Arabia. mabdulla@ksu.edu.sa
Key Words Tumor necrosis factor-; Colorectal cancer; Real time polymerase chain reaction; Immunohistochemistry; mRNA
Core Tip The relative expression of tumor necrosis factor-? (TNF-?) mRNA in colorectal cancer tumor tissue was significantly higher than adjacent normal tissue. In addition, higher TNF-? gene expression was associated significantly with advanced tumor as compared to early tumor stages. Colorectal tumor tissue contained many TNF-? positive cells, whereas normal colorectal tissue contained very few positive cells. We showed elevated TNF-? gene expression by cancer cells, which correlated strongly with advanced tumor stages. High levels of TNF-? expression could be an independent prognostic indicator, and targeting TNF-? may be a promising tool, which can be used to follow-up patients with colorectal carcinoma.
Publish Date 2015-01-06 09:08
Citation Al Obeed OA, Alkhayal KA, Al Sheikh A, Zubaidi AM, Vaali-Mohammed MA, Boushey R, Mckerrow JH, Abdulla MH. Increased expression of tumor necrosis factor-a is associated with advanced colorectal cancer stages. World J Gastroenterol 2014; 20(48): 18390-18396
URL http://www.wjgnet.com/1007-9327/full/v20/i48/18390.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i48.18390
Full Article (PDF) WJG-20-18390.pdf
Full Article (Word) WJG-20-18390.doc
Manuscript File 7253-Review.doc
Answering Reviewers 7253-Answering reviewers.pdf
Copyright License Agreement 7253-Copyright assignment.pdf
Peer-review Report 7253-Peer reviewer(s).pdf
Scientific Misconduct Check 7253-CorssCheck.jpg
Scientific Editor Work List 7253-Scientific editor work list.pdf