Publication Name	World Journal of Transplantation
Manuscript ID	72632
Country	Italy

Received	2021-10-22 08:45
Peer-Review Started	2021-10-22 08:48
To Make the First Decision
Return for Revision	2022-01-22 02:15
Revised	2022-01-27 10:41
Second Decision	2022-03-03 05:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-03-07 00:03
Articles in Press	2022-03-07 00:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-03-10 08:46
Publish the Manuscript Online	2022-03-18 01:31

ISSN	2220-3230 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Transplantation
Manuscript Type	Review
Article Title	Innovative immunosuppression in kidney transplantation: A challenge for unmet needs
Manuscript Source	Invited Manuscript
All Author List	Maurizio Salvadori and Aris Tsalouchos
ORCID	Author(s) ORCID Number Maurizio Salvadori http://orcid.org/0000-0003-1503-2681 Aris Tsalouchos http://orcid.org/0000-0002-8565-4059
Funding Agency and Grant Number
Corresponding Author	Maurizio Salvadori, MD, Professor, Department of Renal Transplantation, Careggi University Hospital, Largo Palagi 1, Florence 50139, Italy. maurizio.salvadori1@gmail.com
Key Words	New drugs; Unmet needs in kidney transplantation; Delayed graft function; Long-term outcomes; Kidney inflammation; Anti-human leukocyte antigen antibodies
Core Tip	Finding new innovative drugs for kidney transplantation is not easy but looking for unmet needs it is possible to find new interesting drugs and opportunities to use in kidney transplantation. Many of these drugs are just at the beginning of their process toward the approval and should be careful checked until the finish of their path. Principal unmet needs are treatment and prevention of delayed graft function, improve the long-term outcomes, desensitization and treatment of acute antibody-mediated rejection. Finding new drugs in these fields results extremely important to face new kind of transplantation as transplant from non-heart beating donor and transplant in ABO incompatibles pairs.
Publish Date	2022-03-18 01:31
Citation	Salvadori M, Tsalouchos A. Innovative immunosuppression in kidney transplantation: A challenge for unmet needs. World J Transplant 2022; 12(3): 27-41
URL	https://www.wjgnet.com/2220-3230/full/v12/i3/27.htm
DOI	https://dx.doi.org/10.5500/wjt.v12.i3.27

Full Article (PDF)	WJT-12-27.pdf
Full Article (Word)	WJT-12-27.docx
Manuscript File	72632_Auto_Edited.docx
Answering Reviewers	72632-Answering reviewers.pdf
Audio Core Tip	72632-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	72632-Conflict-of-interest statement.pdf
Copyright License Agreement	72632-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	72632-Language certificate.pdf
Peer-review Report	72632-Peer-review(s).pdf
Scientific Misconduct Check	72632-Bing-Wang JJ-2.png
Scientific Editor Work List	72632-Scientific editor work list.pdf
CrossCheck Report	72632-CrossCheck report.pdf