| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Case Report |
| Article Title |
Adrenocorticotropic hormone-secreting pancreatic neuroendocrine carcinoma with multiple organ infections and widespread thrombosis: A case report
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Akihiro Yoshihara, Kota Nishihama, Chisa Inoue, Yuko Okano, Kazuhito Eguchi, Soichiro Tanaka, Kanako Maki, Valeria Fridman D'Alessandro, Atsuro Takeshita, Taro Yasuma, Mei Uemura, Toshinari Suzuki, Esteban C Gabazza and Yutaka Yano |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Esteban C Gabazza, MD, PhD, Full Professor, Department of Immunology, Mie University School of Medicine, Mie University, Edobashi 2-174, Tsu 514-8507, Mie, Japan. gabazza@doc.medic.mie-u.ac.jp |
| Key Words |
Neuroendocrine tumors; Cushing's syndrome; Ectopic adrenocorticotropic hormone syndrome; Pneumocystis pneumonia; Pulmonary embolism; Infections; Case report |
| Core Tip |
Adrenocorticotropic hormone (ACTH)-secreting pancreatic neuroendocrine tumor is a rare malignant disease with a poor prognosis. The condition is frequently associated with infectious and thrombotic complications. However, the detailed clinical course and acute complications of the tumor remain unreported. Herein, we report a rare case of ACTH-secreting pancreatic neuroendocrine tumor associated with infections due to multiple pathogens in several organs and systemic coagulopathies. The infectious and thrombotic complications responded well to antibiotics, antiviral and antifungal drugs, and anticoagulants. However, radioisotope studies showed that the tumor was poorly differentiated, rapidly progressive with multiple metastatic lesions in the liver. On this basis, instead of surgical treatment, antitumor chemotherapy was indicated. Unfortunately, the patient died due to systemic tumor dissemination. |
| Publish Date |
2022-06-09 07:17 |
| Citation |
Yoshihara A, Nishihama K, Inoue C, Okano Y, Eguchi K, Tanaka S, Maki K, Fridman D'Alessandro V, Takeshita A, Yasuma T, Uemura M, Suzuki T, Gabazza EC, Yano Y. Adrenocorticotropic hormone-secreting pancreatic neuroendocrine carcinoma with multiple organ infections and widespread thrombosis: A case report. World J Clin Cases 2022; 10(17): 5723-5731 |
| URL |
https://www.wjgnet.com/2307-8960/full/v10/i17/5723.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v10.i17.5723 |
