Publication Name	World Journal of Gastroenterology
Manuscript ID	7269
Country	China

Received	2013-11-12 13:23
Peer-Review Started	2013-11-13 09:16
To Make the First Decision	2013-12-26 10:49
Return for Revision	2013-12-27 15:38
Revised	2014-01-14 09:13
Second Decision	2014-02-20 15:33
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-02-20 15:54
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-04-18 12:24
Typeset the Manuscript	2014-05-21 12:12
Publish the Manuscript Online	2014-06-06 16:55

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Biochemistry & Molecular Biology
Manuscript Type	Autobiography
Article Title	IGFBPrP1 induces liver fibrosis by inducing hepatic stellate cell activation and hepatocyte apoptosis via Smad2/3 signaling
Manuscript Source	Invited Manuscript
All Author List	Yun Zhang, Qian-Qian Zhang, Xiao-Hong Guo, Hai-Yan Zhang and Li-Xin Liu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 30871146 National Natural Science Foundation of China 81141049 Shanxi Provincial Key Scientific Research Projects for the Returned Scholars 2012-4
Corresponding Author	Li-Xin Liu, Professor, Department of Gastroenterology and Hepatology, First Hospital of Shanxi Medical University, Xinjiannan Rd 56, Taiyuan 030001, Shanxi Province, China. lixinliu6@hotmail.com
Key Words	Insulin-like growth factor binding protein-related protein 1; Liver fibrosis; Hepatic stellate cells; Hepatocyte apoptosis; Smad pathway
Core Tip	This study investigated the role and mechanism of insulin-like growth factor binding protein-related protein 1 (IGFBPrP1) in liver fibrosis using an adenovirus vector carrying IGFBPrP1 or a small interfering RNA targeting Smad3. We found that overexpression of IGFBPrP1 induced liver fibrosis by mediating hepatocyte apoptosis and hepatic stellate cells activation. We also identified the important role of the IGFBPrP1-Smad pathway in the regulation of IGFBPrP1 action in the development of liver fibrosis, and this pathway is a potential therapeutic target for liver fibrosis.
Publish Date	2014-06-06 16:55
Citation	Zhang Y, Zhang QQ, Guo XH, Zhang HY, Liu LX. IGFBPrP1 induces liver fibrosis by inducing hepatic stellate cell activation and hepatocyte apoptosis via Smad2/3 signaling. World J Gastroenterol 2014; 20(21): 6523-6533
URL	http://www.wjgnet.com/1007-9327/full/v20/i21/6523.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i21.6523

Full Article (PDF)	WJG-20-6523.pdf
Full Article (Word)	WJG-20-6523.doc
Manuscript File	7269-Review.doc
Answering Reviewers	7269-Answering reviewers.pdf
Copyright License Agreement	7269-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7269-Language certificate.PDF
Peer-review Report	7269-Peer reviews.pdf
Scientific Editor Work List	7269-Scientific editor work list.doc