Publication Name	World Journal of Gastroenterology
Manuscript ID	72700
Country	China

Received	2021-10-26 02:38
Peer-Review Started	2021-10-26 02:40
To Make the First Decision
Return for Revision	2022-04-16 22:18
Revised	2022-04-25 14:50
Second Decision	2022-05-19 03:10
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-05-22 23:12
Articles in Press	2022-05-22 23:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-07-04 07:23
Publish the Manuscript Online	2022-07-13 07:31

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Toxicology
Manuscript Type	Basic Study
Article Title	Activation of natural killer T cells contributes to Th1 bias in the murine liver after 14 d of ethinylestradiol exposure
Manuscript Source	Invited Manuscript
All Author List	Meng-Zhi Zou, Wei-Chao Kong, Heng Cai, Meng-Tao Xing, Zi-Xun Yu, Xin Chen, Lu-Yong Zhang and Xin-Zhi Wang
ORCID	Author(s) ORCID Number Meng-Zhi Zou http://orcid.org/0000-0001-5303-7550 Wei-Chao Kong http://orcid.org/0000-0001-9083-2609 Heng Cai http://orcid.org/0000-0001-6544-2414 Meng-Tao Xing http://orcid.org/0000-0003-3816-4214 Zi-Xun Yu http://orcid.org/0000-0002-7272-7394 Xin Chen http://orcid.org/0000-0002-5330-6543 Lu-Yong Zhang http://orcid.org/0000-0003-1164-7371 Xin-Zhi Wang http://orcid.org/0000-0001-9624-0102
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82073948 National Natural Science Foundation of China 81703626 National Innovation and Entrepreneurship Training Program for Undergraduate 202210316040Z
Corresponding Author	Xin-Zhi Wang, PhD, Associate Research Scientist, New Drug Screening Center, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing 210009, Jiangsu Province, China. wangxz@cpu.edu.cn
Key Words	Natural killer T cell; Th1/Th2; IFN-γ; Estrogen; Cholestasis
Core Tip	In this study, we observed the production of both Th1 and Th2 cytokines by natural killer T (NKT) cells in the liver after 14 d of exposure to ethinylestradiol-induced cholestasis. The liver immune microenvironment was also skewed toward a Th1 bias mainly contributed by NKT cells. Invariant NKT cell deficiency robustly alleviated cholestatic liver damage and downregulated the associated signaling pathways, highlighting the pathogenic role and therapeutic potential of hepatic NKT cells in cholestatic liver diseases.
Publish Date	2022-07-13 07:31
Citation	Zou MZ, Kong WC, Cai H, Xing MT, Yu ZX, Chen X, Zhang LY, Wang XZ. Activation of natural killer T cells contributes to Th1 bias in the murine liver after 14 d of ethinylestradiol exposure. World J Gastroenterol 2022; 28(26): 3150-3163
URL	https://www.wjgnet.com/1007-9327/full/v28/i26/3150.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i26.3150

Full Article (PDF)	WJG-28-3150.pdf
Full Article (Word)	WJG-28-3150.docx
The ARRIVE Guidelines	72700-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	72700_Auto_Edited-LS.docx
Answering Reviewers	72700-Answering reviewers.pdf
Audio Core Tip	72700-Audio core tip.m4a
Biostatistics Review Certificate	72700-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	72700-Conflict-of-interest statement.pdf
Copyright License Agreement	72700-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	72700-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	72700-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	72700-Language certificate.pdf
Peer-review Report	72700-Peer-review(s).pdf
Scientific Editor Work List	72700-Scientific editor work list.pdf
CrossCheck Report	72700-CrossCheck report.pdf