| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Identification of circ_0000375 and circ_0011536 as novel diagnostic biomarkers of colorectal cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Teng-Fei Yin, Shi-Yu Du, Dong-Yan Zhao, Xi-Zhen Sun, Yuan-Chen Zhou, Qian-Qian Wang, Ge-Yu-Jia Zhou and Shu-Kun Yao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Development Plan for Precision Medicine Research |
2017YFC0910002 |
|
| Corresponding Author |
Shu-Kun Yao, MD, PhD, Doctor, Doctor, Professor, Graduate School, Peking University China-Japan Friendship School of Clinical Medicine, No. 2 Yinghua East Road, Chaoyang District, Beijing 100029, China., Beijing 100029, China. shukunyao@126.com |
| Key Words |
Cir_0000375; Circ_0011536; MicroRNA; Biomarker; Colorectal cancer; Tumor suppressor |
| Core Tip |
The dysregulation and biological functions of circular ribonucleic acids (circRNAs) in colorectal cancer (CRC) have not been well elucidated. In this study, circ_0000375 and circ_0011536 were observed to be downregulated in CRC tissues, serum samples and cell lines. These 2 circRNAs were validated as biomarker candidates in tissues and serum samples with high diagnostic performance. Overexpression of circ_0000375 and circ_0011536 inhibited the growth, migration and invasion of CRC cells. Furthermore, miR-1182 and miR-1246 were upregulated in CRC tissues as target microRNA of circ_0000375 and circ_0011536, respectively. Overall, circ_0000375 and circ_0011536 may serve as diagnostic biomarkers and function as tumor suppressors in CRC. |
| Publish Date |
2022-04-08 12:06 |
| Citation |
Yin TF, Du SY, Zhao DY, Sun XZ, Zhou YC, Wang QQ, Zhou GYJ, Yao SK. Identification of circ_0000375 and circ_0011536 as novel diagnostic biomarkers of colorectal cancer. World J Clin Cases 2022; 10(11): 3352-3368 |
| URL |
https://www.wjgnet.com/2307-8960/full/v10/i11/3352.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v10.i11.3352 |
