BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
4/8/2022 12:06:55 PM | Browse: 608 | Download: 1699
 |
Received |
|
2021-10-29 06:24 |
|
Peer-Review Started |
|
2021-10-29 06:27 |
|
First Decision by Editorial Office Director |
|
2021-12-27 04:47 |
|
Return for Revision |
|
2021-12-27 15:55 |
|
Revised |
|
2021-12-30 06:36 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2022-02-11 05:50 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2022-02-13 16:29 |
|
Articles in Press |
|
2022-02-13 16:29 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2022-03-28 01:06 |
|
Publish the Manuscript Online |
|
2022-04-08 12:06 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Identification of circ_0000375 and circ_0011536 as novel diagnostic biomarkers of colorectal cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Teng-Fei Yin, Shi-Yu Du, Dong-Yan Zhao, Xi-Zhen Sun, Yuan-Chen Zhou, Qian-Qian Wang, Ge-Yu-Jia Zhou and Shu-Kun Yao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Development Plan for Precision Medicine Research |
2017YFC0910002 |
|
| Corresponding Author |
Shu-Kun Yao, MD, PhD, Doctor, Doctor, Professor, Graduate School, Peking University China-Japan Friendship School of Clinical Medicine, No. 2 Yinghua East Road, Chaoyang District, Beijing 100029, China., Beijing 100029, China. shukunyao@126.com |
| Key Words |
Cir_0000375; Circ_0011536; MicroRNA; Biomarker; Colorectal cancer; Tumor suppressor |
| Core Tip |
The dysregulation and biological functions of circular ribonucleic acids (circRNAs) in colorectal cancer (CRC) have not been well elucidated. In this study, circ_0000375 and circ_0011536 were observed to be downregulated in CRC tissues, serum samples and cell lines. These 2 circRNAs were validated as biomarker candidates in tissues and serum samples with high diagnostic performance. Overexpression of circ_0000375 and circ_0011536 inhibited the growth, migration and invasion of CRC cells. Furthermore, miR-1182 and miR-1246 were upregulated in CRC tissues as target microRNA of circ_0000375 and circ_0011536, respectively. Overall, circ_0000375 and circ_0011536 may serve as diagnostic biomarkers and function as tumor suppressors in CRC. |
| Publish Date |
2022-04-08 12:06 |
| Citation |
Yin TF, Du SY, Zhao DY, Sun XZ, Zhou YC, Wang QQ, Zhou GYJ, Yao SK. Identification of circ_0000375 and circ_0011536 as novel diagnostic biomarkers of colorectal cancer. World J Clin Cases 2022; 10(11): 3352-3368 |
| URL |
https://www.wjgnet.com/2307-8960/full/v10/i11/3352.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v10.i11.3352 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
