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Articles Published Processes
4/29/2022 6:42:52 AM | Browse: 418 | Download: 974
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Received |
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2021-10-28 11:27 |
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Peer-Review Started |
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2021-10-28 11:29 |
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To Make the First Decision |
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Return for Revision |
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2021-12-12 06:05 |
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Revised |
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2021-12-21 08:37 |
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Second Decision |
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2022-03-18 06:12 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-03-27 05:31 |
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Articles in Press |
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2022-03-27 05:31 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-03-11 21:51 |
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Typeset the Manuscript |
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2022-04-25 02:35 |
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Publish the Manuscript Online |
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2022-04-29 06:42 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Sirtuin1 attenuates acute liver failure by reducing reactive oxygen species via hypoxia inducible factor 1α
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Pan Cao, Qian Chen, Chun-Xia Shi, Lu-Wen Wang and Zuo-Jiong Gong |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China (Major Program) |
8207031232 |
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| Corresponding Author |
Zuo-Jiong Gong, PhD, Full Professor, Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan, China., Renmin Hospital of Wuhan University, Wuhan, China., Renmin Hospital of Wuhan University, 238 Jie Fang Road, Wuhan 430060, People’s Republic of China., Wuhan 430060, Hubei Province, China. zjgong@163.com |
| Key Words |
Acute liver failure; Deacetylation; Hypoxia inducible factor 1α; Reactive oxygen species; Sirtuin 1 |
| Core Tip |
Hypoxia inducible factor 1α (HIF-1α) is a transcription factor that regulates oxygen homeostasis. Under hypoxic conditions, HIF-1α translocates to the nucleus and binds to β-subunits, resulting in transcription of target genes. In acute liver failure, HIF-1α contributes to early liver cell necrosis. The activation of Sirtuin1 (Sirt1) will result in a powerful antioxidant defense system. This study examined the influence of Sirt1-mediated pathways on HIF-1α expression in vivo and in vitro, explored the relationship between Sirt1 and HIF-1α, and further explored its potential mechanism. |
| Publish Date |
2022-04-29 06:42 |
| Citation |
Cao P, Chen Q, Shi CX, Wang LW, Gong ZJ. Sirtuin1 attenuates acute liver failure by reducing reactive oxygen species via hypoxia inducible factor 1α. World J Gastroenterol 2022; 28(17): 1798-1813 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i17/1798.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i17.1798 |
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