Publication Name	World Journal of Clinical Cases
Manuscript ID	7286
Country	Lebanon

Received	2013-11-12 15:20
Peer-Review Started	2013-11-13 14:12
To Make the First Decision	2013-12-02 11:37
Return for Revision	2013-12-13 14:34
Revised	2014-01-02 18:45
Second Decision	2014-02-20 20:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-02-20 20:14
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-12 20:55
Publish the Manuscript Online	2014-03-20 19:24

ISSN	2307-8960 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Case Report
Article Title	Homozygous factor Ⅴ Leiden mutation in type Ⅳ Ehlers-Danlos patient
Manuscript Source	Invited Manuscript
All Author List	Marwan Refaat, Mostafa Hotait and Brion Winston
Funding Agency and Grant Number
Corresponding Author	Marwan Refaat, MD, FACC, FAHA, FHRS, FASE, FESC, FACP, Assistant Professor of Medicine, Department of Cardiology, American University Medical Center, Cairo St, Beirut 110 72020, Lebanon. mr48@aub.edu.lb
Key Words	Ehlers-Danlos syndrome; Factor V Leiden; Platelets; Coagulopathy
Core Tip	Hemostatic abnormalities that have already been described in Ehlers-Danlos syndrome patients include platelet abnormalities (release defects, ?-storage pool disease) as well as clotting factor deficiencies that increase the bleeding tendencies of patients. The coexistence of platelet ?-storage pool disease and factor Ⅴ Leiden mutation in our patient manifested as having aneurysms of the splenic, renal, hepatic, gastric, mesenteric arteries and diffuse aneurysms of the upper and lower extremities as well as bilateral lower extremity deep vein thromboses and pulmonary emboli. This propensity to both bleeding and clotting made the management of our patient challenging on this presentation with acute anterolateral myocardial infarction.
Publish Date	2014-03-20 19:24
Citation	Refaat M, Hotait M, Winston B. Homozygous factor V Leiden mutation in type IV Ehlers-Danlos patient. World J Clin Cases 2014; 2(3): 75-77 Available from: URL: http://www.wjgnet.com/2307-8960/full/v2/i3/75.htm DOI: http://dx.doi.org/10.12998/wjcc.v2.i3.75
URL	http://www.wjgnet.com/2307-8960/full/v2/i3/75.htm
DOI	http://dx.doi.org/10.12998/wjcc.v2.i3.75

Full Article (PDF)	wjcc-2-75.pdf
Full Article (Word)	wjcc-2-75.doc
Manuscript File	7286-Review.doc
Answering Reviewers	7286-Answering reviewers.pdf
Copyright License Agreement	7286-Copyright assignment.pdf
Peer-review Report	7286-Peer reviews.pdf
Scientific Editor Work List	7286-Scientific editor work list.doc