Publication Name	World Journal of Clinical Cases
Manuscript ID	72912
Country	China

Received	2021-12-24 13:50
Peer-Review Started	2021-12-24 13:51
To Make the First Decision
Return for Revision	2022-02-08 09:05
Revised	2022-02-12 12:18
Second Decision	2022-05-10 02:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-05-14 07:22
Articles in Press	2022-05-14 07:22
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-05-08 22:03
Typeset the Manuscript	2022-06-15 10:56
Publish the Manuscript Online	2022-06-24 09:00

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Rheumatology
Manuscript Type	Case Report
Article Title	Immunoadsorption therapy for Klinefelter syndrome with antiphospholipid syndrome in a patient: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	You Song, Yong-Zhen Xiao, Cheng Wang and Rong Du
ORCID	Author(s) ORCID Number You Song http://orcid.org/0000-0002-5235-9790 Yong-Zhen Xiao http://orcid.org/0000-0002-3277-6685 Cheng Wang http://orcid.org/0000-0001-7185-2671 Rong Du http://orcid.org/0000-0002-1676-609X
Funding Agency and Grant Number
Corresponding Author	Rong Du, PhD, Associate Professor, Department of Rheumatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jiefang Avenue, Wuhan 430022, Hubei Province, China. dudurong2003@126.com
Key Words	Klinefelter syndrome; Antiphospholipid syndrome; Immunoadsorption; Glucocorticoid; Cyclophosphamide; Bone morphogenetic protein receptor type-2; Case report
Core Tip	We describe a 31-year-old male patient with chromosome 47 XXY type who suffered from deep vein thrombosis of the lower limbs accompanied by abnormal antiphospholipid antibody, lupus anticoagulant and factor VIII. After treatment with immunoadsorption therapy, glucocorticoids, cyclophosphamide, intravenous immunoglobulin and anticoagulant therapies, the patient showed dramatic symptomatic improvement. During the follow-up, the patient did not develop any new thrombotic events.
Publish Date	2022-06-24 09:00
Citation	Song Y, Xiao YZ, Wang C, Du R. Immunoadsorption therapy for Klinefelter syndrome with antiphospholipid syndrome in a patient: A case report. World J Clin Cases 2022; 10(19): 6580-6586
URL	https://www.wjgnet.com/2307-8960/full/v10/i19/6580.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i19.6580

Full Article (PDF)	WJCC-10-6580.pdf
Full Article (Word)	WJCC-10-6580.docx
Manuscript File	72912_Auto_Edited-YJM-FilipodiaCL-LS.docx
Answering Reviewers	72912-Answering reviewers.pdf
Audio Core Tip	72912-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	72912-Conflict-of-interest statement.pdf
Copyright License Agreement	72912-Copyright license agreement.pdf
Signed Consent for Treatment Form(s) or Document(s)	72912-Informed consent statement.pdf
Peer-review Report	72912-Peer-review(s).pdf
Scientific Editor Work List	72912-Scientific editor work list.pdf
CrossCheck Report	72912-CrossCheck report.pdf