Publication Name	World Journal of Gastroenterology
Manuscript ID	7297
Country	Australia

Received	2013-11-13 07:40
Peer-Review Started	2013-11-13 17:05
To Make the First Decision	2013-12-26 10:48
Return for Revision	2013-12-27 14:36
Revised	2014-02-24 06:01
Second Decision	2014-04-29 12:24
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-29 14:19
Articles in Press	2014-05-23 11:00
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-05-06 19:46
Typeset the Manuscript	2014-07-22 14:16
Publish the Manuscript Online	2014-08-18 16:49

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Natural history of chronic hepatitis B: Phases in a complex relationship
Manuscript Source	Invited Manuscript
All Author List	Catherine MN Croagh and John S Lubel
Funding Agency and Grant Number
Corresponding Author	Catherine MN Croagh, MBBS, FRACP, MPH, Department of Gastroenterology and Hepatology, Eastern Health, Level 2, 5, Arnold st Box Hill, 3128 Victoria, Australia. cmariadason@hotmail.com
Key Words	Hepatitis B; Fibrosis; Natural history; Hepatitis B e antigen; Liver; Cirrhosis; Hepatocellular carcinoma; Genotype
Core Tip	Hepatitis B is a disease of worldwide significance. It involves a complex interplay of viral, host and environmental factors. This review article on the natural history of chronic hepatitis B focuses on the phases of disease. We outline the historical development of these concepts. We describe the specific characteristics of different phases, e.g., the patterns of alanine transaminase abnormalities in the hepatitis B e antigen positive immune clearance phase. Lastly, we review some of the more recent data in relation to the outcomes of various phases, in particular the development of cirrhosis and hepatocellular carcinoma.
Publish Date	2014-08-18 16:49
Citation	Croagh CMN, Lubel JS. Natural history of chronic hepatitis B: Phases in a complex relationship. World J Gastroenterol 2014; 20(30): 10395-10404
URL	http://www.wjgnet.com/1007-9327/full/v20/i30/10395.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i30.10395

Full Article (PDF)	WJG-20-10395.pdf
Full Article (Word)	WJG-20-10395.doc
Manuscript File	7297-Review.docx
Answering Reviewers	7297-Answering reviewers.pdf
Copyright License Agreement	7297-Copyright assignment.pdf
Peer-review Report	7297-Peer reviews.pdf
Scientific Editor Work List	7297-Scientific editor work list.pdf