Publication Name	World Journal of Respirology
Manuscript ID	7299
Country	India

Received	2013-11-27 11:51
Peer-Review Started	2013-11-28 14:06
To Make the First Decision	2013-12-10 14:39
Return for Revision	2013-12-17 17:01
Revised	2013-12-27 17:34
Second Decision	2014-03-17 14:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-03-17 14:52
Articles in Press	2014-05-23 13:15
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-03-21 19:59
Typeset the Manuscript	2014-07-20 21:10
Publish the Manuscript Online	2014-07-25 17:21

ISSN	2218-6255 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Sleep apnea and fatty liver disease: The growing link and management issues
Manuscript Source	Invited Manuscript
All Author List	Surya Prakash Bhatt and Randeep Guleria
Funding Agency and Grant Number
Corresponding Author	Surya Prakash Bhatt, PhD, Senior Research Scientist, Department of Pulmonary Medicine and Sleep Disorders, All India Institute of Medical Sciences, Ansari Nagar East, Gautam Nagar, New Delhi 110029, India. suryabhat@gmail.com
Key Words	Body mass index; Inflammation; Asian Indian; Insulin resistance; Metabolic syndrome
Core Tip	Obstructive sleep apnea (OSA) is associated with non alcoholic fatty liver disease (NAFLD) in animals and humans. Importantly, OSA can aggravate the development of NAFLD to nonalcoholic steatohepatitis in obese individuals. OSA has also been linked to other features of the metabolic syndrome, including dyslipidemia, insulin resistance and hypertension. A wide variety of intermediate phenotypes and genes are involved in sleep apnea and fatty liver which makes this syndrome genetically complex. Lifestyle intervention should be first line treatment for all NAFLD and OSA patients. Several drugs aim to improve metabolic syndrome but need further investigation. Bariatric surgery may improve conditions associated with metabolic syndrome, OSA and NAFLD in the morbidly obese.
Publish Date	2014-07-25 17:21
Citation	Bhatt SP, Guleria R. Sleep apnea and fatty liver disease: The growing link and management issues. World J Respirol 2014; 4(2): 11-18
URL	http://www.wjgnet.com/2218-6255/full/v4/i2/11.htm
DOI	http://dx.doi.org/10.5320/wjr.v4.i2.11

Full Article (PDF)	WJR-4-11.pdf
Full Article (Word)	WJR-4-11.doc
Manuscript File	7299-Review.doc
Answering Reviewers	7299-Answering reviewers.pdf
Copyright License Agreement	7299-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7299-Language certificate.pdf
Peer-review Report	7299-Peer reviews.pdf
Scientific Editor Work List	7299-Scientific editor work list.doc