Publication Name	World Journal of Stem Cells
Manuscript ID	7303
Country	France

Received	2013-11-13 07:55
Peer-Review Started	2013-11-14 09:24
To Make the First Decision	2013-12-02 11:37
Return for Revision	2013-12-12 15:26
Revised
Second Decision	2014-02-20 20:02
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-02-20 20:14
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-04-20 18:53
Publish the Manuscript Online	2014-04-28 14:14

ISSN	1948-0210 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Cell Biology
Manuscript Type	Topic Highlights
Article Title	Brain mesenchymal stem cells: The other stem cells of the brain?
Manuscript Source	Invited Manuscript
All Author List	Florence Appaix, Marie-France Nissou, Boudewijn van der Sanden, Matthieu Dreyfus, François Berger, Jean-Paul Issartel and Didier Wion
Funding Agency and Grant Number	Funding Agency Grant Number INSERM igue contre le Cancer Isère-Rhône Alpes
Corresponding Author	Didier Wion, PhD, INSERM U836, Grenoble Institut des Neurosciences, Bâtiment Edmond J Safra, Université Joseph Fourier, CHU Michallon, 38042 Grenoble, France. didier.wion@ujf-grenoble.fr
Key Words	Stem cell; Mesenchymal stem cell; Pericyte; Brain; Cell plasticity; Cancer stem cell; Glioma; Neurodegenerative disease
Core Tip	Mesenchymal stem cells (MSCs), in addition to their potential to differentiate into cells of the mesenchymal lineage, have immunomodulatory properties and can transdifferentiate to generate neural cells at least in vitro. These stem cells are found in almost any adult tissue, including brain. The existence of similarities between MSC and pericytes points to brain pericytes as the other stem cell population of the adult brain in addition to neural stem cells. This raises fascinating perspectives on the potential of brain pericytes in nervous system maintenance and repair. The recent finding that brain cancer stem cells transdifferentiate into pericytes is another facet of the plasticity of these cells. It suggests that the perversion of the stem cell potential of pericyte might play an even unsuspected role in cancer formation and tumor progression.
Publish Date	2014-04-28 14:14
Citation	Appaix F, Nissou MF, van der Sanden B, Dreyfus M, Berger F, Issartel JP, Wion D. Brain mesenchymal stem cells: The other stem cells of the brain? World J Stem Cells 2014; 6(2): 134-143
URL	http://www.wjgnet.com/1948-0210/full/v6/i2/134.htm
DOI	http://dx.doi.org/10.4252/wjsc.v6.i2.134

Full Article (PDF)	WJSC-6-134.pdf
Full Article (Word)	WJSC-6-134.doc
Manuscript File	7303-Review.docx
Answering Reviewers	7303-Answering reviewers.pdf
Copyright License Agreement	7303-Copyright assignment.pdf
Peer-review Report	7303-Peer reviews.pdf
Scientific Editor Work List	7303-Scientific editor work list.doc