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9/15/2014 6:27:00 PM | Browse: 426 | Download: 339
Publication Name World Journal of Stem Cells
Manuscript ID 7303
Country of Manuscript Source France
2013-11-13 07:55
Peer-Review Started
2013-11-14 09:24
To Make the First Decision
2013-12-02 11:37
Return for Revision
2013-12-12 15:26
Second Decision
2014-02-20 20:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-02-20 20:14
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-04-20 18:53
Publish the Manuscript Online
2014-04-28 14:14
ISSN 1948-0210 (online)
Open Access
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Topic Highlights
Article Title Brain mesenchymal stem cells: The other stem cells of the brain?
Manuscript Source Invited Manuscript
All Author List Florence Appaix, Marie-France Nissou, Boudewijn van der Sanden, Matthieu Dreyfus, François Berger, Jean-Paul Issartel and Didier Wion
Funding Agency and Grant Number
Funding Agency Grant Number
igue contre le Cancer Isère-Rhône Alpes
Corresponding author Didier Wion, PhD, INSERM U836, Grenoble Institut des Neurosciences, Bâtiment Edmond J Safra, Université Joseph Fourier, CHU Michallon, 38042 Grenoble, France. didier.wion@ujf-grenoble.fr
Keywords Stem cell; Mesenchymal stem cell; Pericyte; Brain; Cell plasticity; Cancer stem cell; Glioma; Neurodegenerative disease
Core Tip Mesenchymal stem cells (MSCs), in addition to their potential to differentiate into cells of the mesenchymal lineage, have immunomodulatory properties and can transdifferentiate to generate neural cells at least in vitro. These stem cells are found in almost any adult tissue, including brain. The existence of similarities between MSC and pericytes points to brain pericytes as the other stem cell population of the adult brain in addition to neural stem cells. This raises fascinating perspectives on the potential of brain pericytes in nervous system maintenance and repair. The recent finding that brain cancer stem cells transdifferentiate into pericytes is another facet of the plasticity of these cells. It suggests that the perversion of the stem cell potential of pericyte might play an even unsuspected role in cancer formation and tumor progression.
Publish Date 2014-04-28 14:14
Citation Appaix F, Nissou MF, van der Sanden B, Dreyfus M, Berger F, Issartel JP, Wion D. Brain mesenchymal stem cells: The other stem cells of the brain? World J Stem Cells 2014; 6(2): 134-143
Url http://www.wjgnet.com/1948-0210/full/v6/i2/134.htm
DOI http://dx.doi.org/10.4252/wjsc.v6.i2.134
Full Article (PDF) WJSC-6-134.pdf
Full Article (Word) WJSC-6-134.doc
Manuscript File 7303-Review.docx
Answering Reviewers 7303-Answering reviewers.pdf
Copyright License Agreement 7303-Copyright assignment.pdf
Peer-review Report 7303-Peer reviews.pdf
Scientific Editor Work List 7303-Scientific editor work list.doc