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Articles Published Processes
11/24/2015 3:55:00 PM | Browse: 1119 | Download: 1373
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Received |
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2013-11-13 08:05 |
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Peer-Review Started |
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2013-11-14 09:37 |
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To Make the First Decision |
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2013-12-16 17:13 |
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Return for Revision |
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2013-12-17 14:18 |
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Revised |
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2014-02-21 19:59 |
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Second Decision |
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2014-05-14 09:10 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-05-14 09:41 |
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Articles in Press |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-10-15 15:07 |
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Typeset the Manuscript |
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2015-10-27 09:34 |
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Publish the Manuscript Online |
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2015-11-18 12:39 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Virology |
| Manuscript Type |
Basic Study |
| Article Title |
Hepatitis C virus NS5A promotes insulin resistance through IRS-1 serine phosphorylation and increased gluconeogenesis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Fahed Parvaiz, Sobia Manzoor, Jawed Iqbal, Mehuli Sarkar-Dutta, Muhammad Imran and Gulam Waris |
| Funding Agency and Grant Number |
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| Corresponding Author |
Sobia Manzoor, PhD, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, H-12, Islamabad 44000, Pakistan. lcianunique@yahoo.com |
| Key Words |
Hepatitis C virus nonstructural protein 5A; Insulin resistance; Forkhead box protein 01; Glycogen synthase kinase-beta; Gluconeogenesis |
| Core Tip |
The underlying molecular mechanisms of insulin resistance in response to hepatitis C virus (HCV) infection are poorly understood. Previous studies have demonstrated the effect of HCV core and envelop proteins on insulin signaling in human hepatocytes. However, the role of HCV nonstructural protein 5A (NS5A) in insulin resistance is not known. Our data clearly indicate the role of NS5A in insulin resistance through increased phosphorylation of IRS-1Ser307 and decreased phosphorylation of AktThr308, Fox01Ser256, and GSK3βSer9. |
| Publish Date |
2015-11-18 12:39 |
| Citation |
Parvaiz F, Manzoor S, Iqbal J, Sarkar-Dutta M, Imran M, Waris G. Hepatitis C virus NS5A promotes insulin resistance through IRS-1 serine phosphorylation and increased gluconeogenesis. World J Gastroenterol 2015; 21(43): 12361-12369 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i43/12361.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i43.12361 |
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