| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Basic Study |
| Article Title |
P2X7 receptor blockade decreases inflammation, apoptosis, and enteric neuron loss during Clostridioides difficile toxin A-induced ileitis in mice
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ana A Q A Santos, Deiziane V S Costa, Danielle A Foschetti, Antoniella S G Duarte, Conceição S Martins, Pedro M G Soares, Patricia Castelucci and Gerly A C Brito |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| PRONEX CNPq/FUNCAP |
PR2-0101-00060.01.00/15 |
| São Paulo Research Foundation (FAPESP) |
2014/25927-2 |
| São Paulo Research Foundation (FAPESP) |
2018/07862-1 |
|
| Corresponding Author |
Gerly A C Brito, MD, PhD, Professor, Department of Morphology, Federal University of Ceara, Rua Delmiro de Farias, Fortaleza 60140-170, Ceara, Brazil. gerlybrito@gmail.com |
| Key Words |
Clostridioides difficile; Clostridioides difficile toxin A; P2X7 receptor; Enteric nervous system; Enteric neuron; Enteric glia |
| Core Tip |
There is a knowledge gap regarding the population of enteric neurons affected by TcdA and the role of the P2X7 receptor, which is a low-sensitivity adenosine triphosphate-gated cation channel, in TcdA-induced alterations in enteric neurons and enteric glial cell (EGC)-derived mediators, particularly S100B. The findings of the present study demonstrated the mechanism of P2X7 receptor-driven enteric neuronal loss induced by TcdA in the mouse ileum. TcdA promoted the upregulation of the P2X7 receptor, which promoted cell death in enteric neurons and induced the release of proinflammatory mediators, which in turn promoted S100B synthesis in EGCs. However, the blockade of the P2X7 receptor abrogated ileal damage induced by TcdA. |
| Publish Date |
2022-08-10 08:23 |
| Citation |
Santos AAQA, Costa DVS, Foschetti DA, Duarte ASG, Martins CS, Soares PMG, Castelucci P, Brito GAC. P2X7 receptor blockade decreases inflammation, apoptosis, and enteric neuron loss during Clostridioides difficile toxin A-induced ileitis in mice. World J Gastroenterol 2022; 28(30): 4075-4088 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i30/4075.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i30.4075 |
