Publication Name	World Journal of Psychiatry
Manuscript ID	73108
Country	Italy

Received	2021-11-12 14:19
Peer-Review Started	2021-11-12 14:21
To Make the First Decision
Return for Revision	2021-12-12 07:42
Revised	2022-01-03 15:35
Second Decision	2022-02-22 03:28
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-02-23 20:50
Articles in Press	2022-02-23 20:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-03-09 02:02
Publish the Manuscript Online	2022-03-18 12:26

ISSN	2220-3206 (online)
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Category	Genetics & Heredity
Manuscript Type	Letter to the Editor
Article Title	Does COVID-19 increase the risk of neuropsychiatric sequelae? Evidence from a mendelian randomization approach
Manuscript Source	Invited Manuscript
All Author List	Alfonsina Tirozzi, Federica Santonastaso, Giovanni de Gaetano, Licia Iacoviello and Alessandro Gialluisi
ORCID	Author(s) ORCID Number Alfonsina Tirozzi http://orcid.org/0000-0002-6052-1807 Federica Santonastaso http://orcid.org/0000-0001-7105-7504 Giovanni de Gaetano http://orcid.org/0000-0002-7823-1402 Licia Iacoviello http://orcid.org/0000-0003-0514-5885 Alessandro Gialluisi http://orcid.org/0000-0002-7388-4463
Funding Agency and Grant Number	Funding Agency Grant Number Fondazione Umberto Veronesi NA
Corresponding Author	Licia Iacoviello, MD, PhD, Professor, Department of Epidemiology and Prevention, IRCCS NEUROMED, Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo Neuromed, Via Atinense 18, Pozzilli 86077, Italy. licia.iacoviello@moli-sani.org
Key Words	COVID-19; Sars-CoV-2; Neurological disorders; Neuropsychiatric disorders; Alzheimer’s disease; Anxiety; Mendelian randomization
Core Tip	Inspired by suggestive findings of an increased incident risk of neurological and neuropsychiatric sequelae in people who have had coronavirus disease 2019 (COVID-19), we carried out a two-sample Mendelian randomization analysis to further investigate causality links and build evidence free of biases such as unmeasured confounding, residual reverse causality or lack of precision in electronic health record-based diagnoses. This analysis – typically applied to genetic associations from large genomic studies on the diseases of interest – indicated that the most severe forms of COVID-19 increased the risk of Alzheimer’s disease and anxiety, further supporting the findings of large observational studies.
Publish Date	2022-03-18 12:26
Citation	Tirozzi A, Santonastaso F, de Gaetano G, Iacoviello L, Gialluisi A. Does COVID-19 increase the risk of neuropsychiatric sequelae? Evidence from a mendelian randomization approach. World J Psychiatry 2022; 12(3): 536-540
URL	https://www.wjgnet.com/2220-3206/full/v12/i3/536.htm
DOI	https://dx.doi.org/10.5498/wjp.v12.i3.536

Full Article (PDF)	WJP-12-536.pdf
Full Article (Word)	WJP-12-536.docx
Manuscript File	73108_Auto_Edited.docx
Answering Reviewers	73108-Answering reviewers.pdf
Audio Core Tip	73108-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	73108-Conflict-of-interest statement.pdf
Copyright License Agreement	73108-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	73108-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	73108-Language certificate.pdf
Peer-review Report	73108-Peer-review(s).pdf
Scientific Misconduct Check	73108-Bing-Wu YXJ-2.png
Scientific Editor Work List	73108-Scientific editor work list.pdf
CrossCheck Report	73108-CrossCheck report.pdf