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Articles Published Processes
8/10/2022 1:14:37 PM | Browse: 646 | Download: 1939
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Received |
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2021-11-11 07:52 |
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Peer-Review Started |
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2021-11-11 07:53 |
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First Decision by Editorial Office Director |
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2021-12-27 04:40 |
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Return for Revision |
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2021-12-27 04:40 |
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Revised |
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2022-01-06 19:05 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2022-07-19 03:08 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2022-07-22 03:59 |
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Articles in Press |
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2022-07-22 03:59 |
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Edit the Manuscript by Language Editor |
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2022-07-08 03:17 |
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Typeset the Manuscript |
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2022-07-26 00:30 |
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Publish the Manuscript Online |
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2022-08-10 13:14 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
KAI1/CD82 gene and autotaxin-lysophosphatidic acid axis in gastrointestinal cancers
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shuo Wang, Jiang Chen and Xiao-Zhong Guo |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81672465 |
| Science and Technology Program of Liaoning Province |
2019JH8/10300080 |
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| Corresponding Author |
Xiao-Zhong Guo, PhD, Chief Doctor, Chief Physician, Director, Director, Professor, Department of Gastroenterology, General Hospital of Northern Theater Command, No. 83 Wenhua Road, Shenyang 110840, Liaoning Province, China. guoxiaozhong1962@126.com |
| Key Words |
KAI1/CD82; Autotaxin; Lysophosphatidic acid; Pancreatic cancer; Liver cancer |
| Core Tip |
The KAI1/CD82 gene inhibits the metastasis of most tumors and is significantly correlated with their invasion and prognosis. According to our recent pre-experimental results, we speculated that KAI1/CD82 might inhibit the migration and metastasis of cancer cells by regulating autotaxin (ATX)-lysophosphatidic acid (LPA) axis. However, no relevant research has been reported. To clarify the mechanism of ATX-LPA in KAI1/CD82 inhibition of cancer metastasis will provide an important theoretical basis for targeted cancer therapy, and further research is necessary. In this paper, the molecular composition of the KAI1/CD82 gene and ATX-LPA axis, their physiological functions in tumors, and their roles in gastrointestinal cancers and target therapy are reviewed. |
| Publish Date |
2022-08-10 13:14 |
| Citation |
Wang S, Chen J, Guo XZ. KAI1/CD82 gene and autotaxin-lysophosphatidic acid axis in gastrointestinal cancers. World J Gastrointest Oncol 2022; 14(8): 1388-1405 |
| URL |
https://www.wjgnet.com/1948-5204/full/v14/i8/1388.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v14.i8.1388 |
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