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Articles Published Processes
8/10/2022 8:23:14 AM | Browse: 453 | Download: 1398
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Received |
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2021-11-26 14:24 |
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Peer-Review Started |
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2021-11-26 14:27 |
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To Make the First Decision |
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Return for Revision |
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2022-01-08 18:34 |
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Revised |
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2022-01-21 16:06 |
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Second Decision |
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2022-07-14 03:02 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-07-17 23:41 |
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Articles in Press |
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2022-07-17 23:41 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-07-01 01:16 |
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Typeset the Manuscript |
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2022-07-29 09:23 |
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Publish the Manuscript Online |
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2022-08-10 08:23 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Salivary Fusobacterium nucleatum serves as a potential diagnostic biomarker for gastric cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Wen-Dan Chen, Xin Zhang, Meng-Jiao Zhang, Ya-Ping Zhang, Zi-Qi Shang, Yi-Wei Xin and Yi Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81972005, 82172339 |
| Natural Science Foundation of Shandong Province |
ZR2020MH238 |
| Shandong Medical and Health Technology Development Project |
2018WS327 |
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| Corresponding Author |
Yi Zhang, PhD, Professor, Department of Clinical Laboratory, Qilu Hospital of Shandong University, No. 107 Wenhua Xi Road, Jinan 250012, Shandong Province, China. yizhang@sdu.edu.cn |
| Key Words |
Gastric cancer; Fusobacterium nucleatum; Saliva; Prognosis; Metastasis; Epithelial-mesenchymal transition |
| Core Tip |
Fusobacterium nucleatum (Fn), known as a periodontal pathogen, is frequently detected in tissues of gastrointestinal tumor. Here, we found that the level of salivary Fn was increased in gastric cancer (GC) patients, which could be used as a potential biomarker for GC diagnosis, and its diagnostic capability was superior to that of traditional serum tumor markers. We also showed that salivary Fn level was positively associated with the GC TNM stage and lymph node metastasis. Further, experiments in vitro revealed that Fn could promote the migration and invasion of GC cells by promoting the epithelial-mesenchymal transition process. Our findings suggest that salivary Fn is a potential biomarker in diagnosis of GC. |
| Publish Date |
2022-08-10 08:23 |
| Citation |
Chen WD, Zhang X, Zhang MJ, Zhang YP, Shang ZQ, Xin YW, Zhang Y. Salivary Fusobacterium nucleatum serves as a potential diagnostic biomarker for gastric cancer. World J Gastroenterol 2022; 28(30): 4120-4132 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i30/4120.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i30.4120 |
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