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Articles Published Processes
1/13/2022 11:55:40 AM | Browse: 613 | Download: 1400
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Received |
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2021-11-15 21:02 |
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Peer-Review Started |
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2021-11-15 21:04 |
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First Decision by Editorial Office Director |
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2021-11-22 03:28 |
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Return for Revision |
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2021-11-22 03:28 |
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Revised |
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2021-12-02 05:42 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2022-01-11 03:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2022-01-11 19:34 |
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Articles in Press |
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2022-01-11 19:34 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-01-12 04:56 |
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Publish the Manuscript Online |
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2022-01-13 11:55 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Frontier |
| Article Title |
Endothelial cells and blood vessels are major targets for COVID-19-induced tissue injury and spreading to various organs
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Andrzej S Tarnawski and Amrita Ahluwalia |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Amrita Ahluwalia, PhD, Research Scientist, Research Service, Veterans Administration Long Beach Healthcare System, 5901 E, Seventh Street, Long Beach, CA 90822, United States. amrita.ahluwalia@va.gov |
| Key Words |
Endothelial cells; Impaired endothelial function; Blood vessels; SARS-CoV-2; COVID-19; Cytokine storm |
| Core Tip |
The coronavirus disease 2019 (COVID-19) pandemic has enormous health care and economic impact on the entire world - infecting more than 250 million people in 213 countries and territories, causing death of more than 5 million (as of November 1, 2021). We comment here on some outstanding papers on COVID-19 published in World Journal of Gastroenterology and reviewed the important role of endothelium and blood vessels in COVID-19 infection. Endothelial cells and blood vessels are both the targets and a conduit for the spread of severe acute respiratory syndrome coronavirus 2 and play a critical role in COVID-19-induced tissue injury and dissemination to various organs. Pre-existing endothelial impaired function could make endothelial cells more sensitive to COVID-19 or at least COVID-19-induced impairment might be synergistic with pre-existing impairment. That could be one contributing factor explaining why older or diabetic patients have more severe responses to infection, since these conditions are already impacted impaired endothelial function. |
| Publish Date |
2022-01-13 11:55 |
| Citation |
Tarnawski AS, Ahluwalia A. Endothelial cells and blood vessels are major targets for COVID-19-induced tissue injury and spreading to various organs. World J Gastroenterol 2022; 28(3): 275-289 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i3/275.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i3.275 |
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