| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Prognostic factors of recurrent intrahepatic cholangiocarcinoma after hepatectomy: A retrospective study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zi-Bo Yuan, Hong-Bo Fang, Quan-Kai Feng, Tao Li and Jie Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Medical Science and Technology Project of Henan Province |
SBGJ2018024 |
|
| Corresponding Author |
Jie Li, MD, PhD, Director, Doctor, Professor, Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Zhengzhou 450052, Henan, China. ljljdoctor@126.com |
| Key Words |
Intrahepatic cholangiocarcinoma; Hepatectomy; Recurrence; Multimodality therapy; Prognosis |
| Core Tip |
With this 8-year retrospective study, we aimed to investigate the clinical characteristics, analyse the prognostic factors, and discuss therapeutic strategies for patients with recurrent intrahepatic cholangiocarcinoma (ICC) after hepatectomy. Multivariate analysis showed that alcohol consumption [hazard ratio (HR) = 4.64, 95% confidence interval (CI): 1.53-14.04, P = 0.007] and disease-free survival < 6 mo (HR=3.47, 95%CI: 1.59-7.60, P = 0.002) were independent risk factors for cumulative survival for patients with recurrence, while treatment after recurrence (HR=0.21, 95%CI: 0.08-0.55, P = 0.001) was an independent protective factor. We propose that multimodality therapy should be developed to improve long-term outcomes through the combined approach of local therapy, chemotherapy, targeted therapy, and immunotherapy. |
| Publish Date |
2022-04-15 08:25 |
| Citation |
Yuan ZB, Fang HB, Feng QK, Li T, Li J. Prognostic factors of recurrent intrahepatic cholangiocarcinoma after hepatectomy: A retrospective study. World J Gastroenterol 2022; 28(15): 1574-1587 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i15/1574.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i15.1574 |
