| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Intrathecal methotrexate in combination with systemic chemotherapy in glioblastoma patients with leptomeningeal dissemination: A retrospective analysis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xun Kang, Feng Chen, Shou-Bo Yang, Ya-Li Wang, Zeng-Hui Qian, Yan Li, Hao Lin, Parker Li, Yi-Chen Peng, Xiao-Min Wang and Wen-Bin Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China (General Program) |
81972338 |
|
| Corresponding Author |
Wen-Bin Li, Doctor, MD, Chief Doctor, Professor, Department of Neuro-oncology, Cancer Center, Beijing Tiantan Hospital, Capital Medical University, No.119 South Fourth Ring West Road, Fengtai District, Beijing, Beijing 100070, China. liwenbin@ccmu.edu.cn |
| Key Words |
Glioma; Glioblastoma; Leptomeningeal dissemination; Intrathecal methotrexate; Chemotherapy |
| Core Tip |
Glioblastoma (GBM) patients with leptomeningeal dissemination (LMD) have severe symptoms and poor prognosis. We investigated the use of intrathecal methotrexate in combination with systemic chemotherapy in terms of effectivity and patient outcome. We showed the potential effectivity of this treatment and that KPS > 60, gross resection of the brain tumor, and the Ommaya reservoir implantation are positive prognostic factors for patients with LMD. We believe that our study gives evidence systemetic treatment is potentially effective in GBM patients with LMD. |
| Publish Date |
2022-06-09 07:17 |
| Citation |
Kang X, Chen F, Yang SB, Wang YL, Qian ZH, Li Y, Lin H, Li P, Peng YC, Wang XM, Li WB. Intrathecal methotrexate in combination with systemic chemotherapy in glioblastoma patients with leptomeningeal dissemination: A retrospective analysis. World J Clin Cases 2022; 10(17): 5595-5605 |
| URL |
https://www.wjgnet.com/2307-8960/full/v10/i17/5595.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v10.i17.5595 |
