Publication Name	World Journal of Clinical Cases
Manuscript ID	73320
Country	China

Received	2021-11-23 15:04
Peer-Review Started	2021-11-23 15:05
To Make the First Decision
Return for Revision	2022-01-22 01:42
Revised	2022-01-30 08:42
Second Decision	2022-03-28 05:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-04-04 03:34
Articles in Press	2022-04-04 03:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-05-24 09:37
Publish the Manuscript Online	2022-06-09 07:17

ISSN	2307-8960 (online)
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Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Intrathecal methotrexate in combination with systemic chemotherapy in glioblastoma patients with leptomeningeal dissemination: A retrospective analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Xun Kang, Feng Chen, Shou-Bo Yang, Ya-Li Wang, Zeng-Hui Qian, Yan Li, Hao Lin, Parker Li, Yi-Chen Peng, Xiao-Min Wang and Wen-Bin Li
ORCID	Author(s) ORCID Number Xun Kang http://orcid.org/0000-0002-8940-8402 Feng Chen http://orcid.org/0000-0003-4819-2518 Shou-Bo Yang http://orcid.org/0000-0003-1126-5461 Ya-Li Wang http://orcid.org/0000-0003-2258-584X Zeng-Hui Qian http://orcid.org/0000-0002-9713-1028 Yan Li http://orcid.org/0000-0001-9688-0257 Hao Lin http://orcid.org/0000-0003-0807-8462 Parker Li http://orcid.org/0000-0002-4660-7321 Yi-Chen Peng http://orcid.org/0000-0003-0358-5422 Xiao-Min Wang http://orcid.org/0000-0002-0516-5061 Wen-Bin Li http://orcid.org/0000-0001-7638-4395
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China (General Program) 81972338
Corresponding Author	Wen-Bin Li, Doctor, MD, Chief Doctor, Professor, Department of Neuro-oncology, Cancer Center, Beijing Tiantan Hospital, Capital Medical University, No.119 South Fourth Ring West Road, Fengtai District, Beijing, Beijing 100070, China. liwenbin@ccmu.edu.cn
Key Words	Glioma; Glioblastoma; Leptomeningeal dissemination; Intrathecal methotrexate; Chemotherapy
Core Tip	Glioblastoma (GBM) patients with leptomeningeal dissemination (LMD) have severe symptoms and poor prognosis. We investigated the use of intrathecal methotrexate in combination with systemic chemotherapy in terms of effectivity and patient outcome. We showed the potential effectivity of this treatment and that KPS > 60, gross resection of the brain tumor, and the Ommaya reservoir implantation are positive prognostic factors for patients with LMD. We believe that our study gives evidence systemetic treatment is potentially effective in GBM patients with LMD.
Publish Date	2022-06-09 07:17
Citation	Kang X, Chen F, Yang SB, Wang YL, Qian ZH, Li Y, Lin H, Li P, Peng YC, Wang XM, Li WB. Intrathecal methotrexate in combination with systemic chemotherapy in glioblastoma patients with leptomeningeal dissemination: A retrospective analysis. World J Clin Cases 2022; 10(17): 5595-5605
URL	https://www.wjgnet.com/2307-8960/full/v10/i17/5595.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i17.5595

Full Article (PDF)	WJCC-10-5595.pdf
Full Article (Word)	WJCC-10-5595.docx
Manuscript File	73320_Auto_Edited-LJH.docx
Answering Reviewers	73320-Answering reviewers.pdf
Audio Core Tip	73320-Audio core tip.m4a
Biostatistics Review Certificate	73320-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	73320-Conflict-of-interest statement.pdf
Copyright License Agreement	73320-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	73320-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	73320-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	73320-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	73320-Language certificate.pdf
Peer-review Report	73320-Peer-review(s).pdf
Scientific Misconduct Check	73320-Bing-Liu JH-2.jpg
Scientific Misconduct Check	73320-CrossCheck.jpg
Scientific Editor Work List	73320-Scientific editor work list.pdf