Publication Name	World Journal of Cardiology
Manuscript ID	73324
Country	China

Received	2021-12-14 02:31
Peer-Review Started	2021-12-14 02:33
To Make the First Decision
Return for Revision	2022-01-25 08:49
Revised	2022-02-19 17:47
Second Decision	2022-04-18 02:16
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-04-26 19:15
Articles in Press	2022-04-26 19:15
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-04-12 04:18
Typeset the Manuscript	2022-05-13 10:34
Publish the Manuscript Online	2022-05-18 08:53

ISSN	1949-8462 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Engineering, Biomedical
Manuscript Type	Basic Study
Article Title	Bioinformatics prediction of potential mechanisms and biomarkers underlying dilated cardiomyopathy
Manuscript Source	Invited Manuscript
All Author List	Zhou Liu, Ying-Nan Song, Kai-Yuan Chen, Wei-Long Gao, Hong-Jin Chen and Gui-You Liang
ORCID	Author(s) ORCID Number Zhou Liu http://orcid.org/0000-0002-6773-1073 Ying-Nan Song http://orcid.org/0000-0003-4464-0512 Kai-Yuan Chen http://orcid.org/0000-0002-0375-1091 Wei-Long Gao http://orcid.org/0000-0002-0464-970X Hong-Jin Chen http://orcid.org/0000-0002-0513-9584 Gui-You Liang http://orcid.org/0000-0002-4555-9102
Funding Agency and Grant Number	Funding Agency Grant Number National Nature Science Foundation of China 81960051 National Nature Science Foundation of China 8217021743 National Nature Science Foundation of China 82160060 Project of High–Level Innovative Talents of Guizhou Province [2016]4034 Construction Funding from Characteristic Key Laboratory of Guizhou Province [2021]313
Corresponding Author	Gui-You Liang, MD, Professor, School of Basic Medical Sciences, Guizhou Medical University, Dangwu, Guian District, Guiyang 550025, Guizhou Province, China. guiyou515@163.com
Key Words	Dilated cardiomyopathy; Bioinformatics; Differentially expressed genes; Function enrichment analysis; Protein-protein interaction network; Immune cell infiltration
Core Tip	As the most common cause of heart failure, the diagnosis and therapy for dilated cardiomyopathy (DCM) are still unsatisfactory because of its indistinct pathogenesis and specific biomarkers. Thus, we comprehensively utilized the microarray data from the Gene Expression Omnibus database to uncover the biomarker and mechanisms underlying DCM development. Collagen type III alpha 1 chain and collagen type I alpha 2 chain, which are regulated by hsa-miR-5682 and hsa-miR-4500, may play critical roles in the pathogenesis of DCM through the acute inflammatory response and interleukin 17 signaling pathway. These biomarkers and mechanisms need to be further studied.
Publish Date	2022-05-18 08:53
Citation	Liu Z, Song YN, Chen KY, Gao WL, Chen HJ, Liang GY. Bioinformatics prediction of potential mechanisms and biomarkers underlying dilated cardiomyopathy. World J Cardiol 2022; 14(5): 282-296
URL	https://www.wjgnet.com/1949-8462/full/v14/i5/282.htm
DOI	https://dx.doi.org/10.4330/wjc.v14.i5.282

Full Article (PDF)	WJC-14-282.pdf
Full Article (Word)	WJC-14-282.docx
Manuscript File	73324_Auto_Edited_LM.docx
Answering Reviewers	73324-Answering reviewers.pdf
Audio Core Tip	73324-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	73324-Conflict-of-interest statement.pdf
Copyright License Agreement	73324-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	73324-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	73324-Language certificate.pdf
Peer-review Report	73324-Peer-review(s).pdf
Scientific Editor Work List	73324-Scientific editor work list.pdf