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Articles Published Processes
5/18/2022 8:53:39 AM | Browse: 384 | Download: 636
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Received |
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2021-12-14 02:31 |
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Peer-Review Started |
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2021-12-14 02:33 |
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To Make the First Decision |
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Return for Revision |
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2022-01-25 08:49 |
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Revised |
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2022-02-19 17:47 |
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Second Decision |
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2022-04-18 02:16 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-04-26 19:15 |
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Articles in Press |
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2022-04-26 19:15 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-04-12 04:18 |
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Typeset the Manuscript |
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2022-05-13 10:34 |
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Publish the Manuscript Online |
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2022-05-18 08:53 |
| ISSN |
1949-8462 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Engineering, Biomedical |
| Manuscript Type |
Basic Study |
| Article Title |
Bioinformatics prediction of potential mechanisms and biomarkers underlying dilated cardiomyopathy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Zhou Liu, Ying-Nan Song, Kai-Yuan Chen, Wei-Long Gao, Hong-Jin Chen and Gui-You Liang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Nature Science Foundation of China |
81960051 |
| National Nature Science Foundation of China |
8217021743 |
| National Nature Science Foundation of China |
82160060 |
| Project of High–Level Innovative Talents of Guizhou Province |
[2016]4034 |
| Construction Funding from Characteristic Key Laboratory of Guizhou Province |
[2021]313 |
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| Corresponding Author |
Gui-You Liang, MD, Professor, School of Basic Medical Sciences, Guizhou Medical University, Dangwu, Guian District, Guiyang 550025, Guizhou Province, China. guiyou515@163.com |
| Key Words |
Dilated cardiomyopathy; Bioinformatics; Differentially expressed genes; Function enrichment analysis; Protein-protein interaction network; Immune cell infiltration |
| Core Tip |
As the most common cause of heart failure, the diagnosis and therapy for dilated cardiomyopathy (DCM) are still unsatisfactory because of its indistinct pathogenesis and specific biomarkers. Thus, we comprehensively utilized the microarray data from the Gene Expression Omnibus database to uncover the biomarker and mechanisms underlying DCM development. Collagen type III alpha 1 chain and collagen type I alpha 2 chain, which are regulated by hsa-miR-5682 and hsa-miR-4500, may play critical roles in the pathogenesis of DCM through the acute inflammatory response and interleukin 17 signaling pathway. These biomarkers and mechanisms need to be further studied. |
| Publish Date |
2022-05-18 08:53 |
| Citation |
Liu Z, Song YN, Chen KY, Gao WL, Chen HJ, Liang GY. Bioinformatics prediction of potential mechanisms and biomarkers underlying dilated cardiomyopathy. World J Cardiol 2022; 14(5): 282-296 |
| URL |
https://www.wjgnet.com/1949-8462/full/v14/i5/282.htm |
| DOI |
https://dx.doi.org/10.4330/wjc.v14.i5.282 |
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