Publication Name	World Journal of Gastroenterology
Manuscript ID	7338
Country	Japan

Received	2013-11-14 07:52
Peer-Review Started	2013-11-14 17:24
First Decision by Editorial Office Director
Return for Revision	2013-12-17 13:57
Revised	2014-01-06 14:46
Publication Fee Transferred
Second Decision by Editor	2014-06-17 09:11
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-06-17 09:41
Articles in Press	2014-06-17 10:07
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-04 10:53
Publish the Manuscript Online	2014-11-20 20:51

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	MK-0626, a selective DPP-4 inhibitor, attenuates hepatic steatosis in ob/ob mice
Manuscript Source	Invited Manuscript
All Author List	Tatsuya Ohyama, Ken Sato, Yuichi Yamazaki, Hiroaki Hashizume, Norio Horiguchi, Satoru Kakizaki, Masatomo Mori, Motoyasu Kusano and Masanobu Yamada
Funding Agency and Grant Number	Funding Agency Grant Number Merck Sharp and Dohme
Corresponding Author	Ken Sato, M.D., Ph.D., Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan. Phone: +81-27-220-8127 Fax: +81-27-220-8136 E-mail: satoken@showa.gunma-u.ac.jp
Key Words	Dipeptidyl peptidase-4 inhibitor; Hepatic steatosis; ob/ob mice; AMP-activated protein kinase; Microsomal triglyceride transfer protein; Adiponectin
Core Tip	Administration of a DPP-4 inhibitor, MK-0626 ameliorated hepatic steatosis, serum ALT levels, glucose levels, insulin levels and calculated HOMA scores and increased serum adiponectin levels in ob/ob mice. MK-0626 treatment significantly increased the mRNA expression of peroxisome proliferator-activated receptor α and microsomal triglyceride transfer protein but significantly reduced sterol regulatory element binding transcription factor-1c, fatty acid synthase and stearoyl-CoA desaturase-1. The activity of AMP-activated protein kinase (AMPK) was significantly increased. These results suggested that MK-0626 could attenuate hepatic steatosis through enhancing AMPK activity, inhibiting hepatic lipogenic gene expression, enhancing triglyceride secretion from liver and increasing serum adiponectin levels.
Publish Date	2014-11-20 20:51
Citation	Ohyama T, Sato K, Yamazaki Y, Hashizume H, Horiguchi N, Kakizaki S, Mori M, Kusano M, Yamada M. MK-0626, a selective DPP-4 inhibitor, attenuates hepatic steatosis in ob/ob mice. World J Gastroenterol 2014; 20(43): 16227-16235
URL	http://www.wjgnet.com/1007-9327/full/v20/i43/16227.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i43.16227

Full Article (PDF)	WJG-20-16227.pdf
Full Article (Word)	WJG-20-16227.doc
Manuscript File	7338-Review.doc
Answering Reviewers	7338-Answering reviewers.pdf
Copyright License Agreement	7338-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7338-Language certificate.pdf
Peer-review Report	7338-Peer reviews.pdf
Scientific Misconduct Check	7338-CrossCheck.jpg
Scientific Editor Work List	7338-Scientific editor work list.pdf