| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
MK-0626, a selective DPP-4 inhibitor, attenuates hepatic steatosis in ob/ob mice
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Tatsuya Ohyama, Ken Sato, Yuichi Yamazaki, Hiroaki Hashizume, Norio Horiguchi, Satoru Kakizaki, Masatomo Mori, Motoyasu Kusano and Masanobu Yamada |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Merck Sharp and Dohme |
|
|
| Corresponding Author |
Ken Sato, M.D., Ph.D.,
Department of Medicine and Molecular Science,
Gunma University Graduate School of Medicine,
3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan.
Phone: +81-27-220-8127
Fax: +81-27-220-8136
E-mail: satoken@showa.gunma-u.ac.jp
|
| Key Words |
Dipeptidyl peptidase-4 inhibitor; Hepatic steatosis; ob/ob mice; AMP-activated protein kinase; Microsomal triglyceride transfer protein; Adiponectin |
| Core Tip |
Administration of a DPP-4 inhibitor, MK-0626 ameliorated hepatic steatosis, serum ALT levels, glucose levels, insulin levels and calculated HOMA scores and increased serum adiponectin levels in ob/ob mice. MK-0626 treatment significantly increased the mRNA expression of peroxisome proliferator-activated receptor α and microsomal triglyceride transfer protein but significantly reduced sterol regulatory element binding transcription factor-1c, fatty acid synthase and stearoyl-CoA desaturase-1. The activity of AMP-activated protein kinase (AMPK) was significantly increased. These results suggested that MK-0626 could attenuate hepatic steatosis through enhancing AMPK activity, inhibiting hepatic lipogenic gene expression, enhancing triglyceride secretion from liver and increasing serum adiponectin levels. |
| Publish Date |
2014-11-20 20:51 |
| Citation |
Ohyama T, Sato K, Yamazaki Y, Hashizume H, Horiguchi N, Kakizaki S, Mori M, Kusano M, Yamada M. MK-0626, a selective DPP-4 inhibitor, attenuates hepatic steatosis in ob/ob mice. World J Gastroenterol 2014; 20(43): 16227-16235 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i43/16227.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i43.16227 |
