Publication Name	World Journal of Gastroenterology
Manuscript ID	7341
Country	Spain

Received	2013-11-14 07:59
Peer-Review Started	2013-11-14 18:24
To Make the First Decision	2014-02-13 16:02
Return for Revision	2014-02-20 14:33
Revised	2014-02-21 22:00
Second Decision	2014-04-23 09:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-04-23 10:07
Articles in Press	2014-05-23 09:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-26 16:26
Publish the Manuscript Online	2014-08-18 16:49

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Nutrition & Dietetics
Manuscript Type	Topic Highlights
Article Title	Bowman-Birk inhibitors from legumes as colorectal chemopreventive agents
Manuscript Source	Invited Manuscript
All Author List	Alfonso Clemente and Maria del Carmen Arques
Funding Agency and Grant Number
Corresponding Author	Alfonso Clemente, PhD, Department of Physiology and Biochemistry of Nutrition, Estación Experimental del Zaidín (CSIC), Profesor Albareda 1, 18008 Granada, Spain. alfonso.clemente@eez.csic.es
Key Words	Bowman-Birk inhibitors; Cell proliferation; Chemoprevention; Colorectal cancer; Legumes; Serine proteases
Core Tip	Bowman-Birk inhibitors (BBI) from legumes, such as soybean, pea, lentil and chickpea, are a class of naturally-occurring serine protease inhibitors with potential anti-inflammatory and chemopreventive properties within the gastrointestinal tract (GIT). BBI are extensively disulphide-linked within proteins and have been demonstrated to be structurally and functionally resistant to the challenges of the GIT in vivo. Recent data suggest that trypsin- and chymotrypsin-like proteases involved in early stages of carcinogenesis should be primary targets in investigating the potential of BBI as colorectal chemopreventive agents; so far, the therapeutic targets as well as action mechanism of BBI remain unknown.
Publish Date	2014-08-18 16:49
Citation	Clemente A, Arques MC. Bowman-Birk inhibitors from legumes as colorectal chemopreventive agents. World J Gastroenterol 2014; 20(30): 10305-10315
URL	http://www.wjgnet.com/1007-9327/full/v20/i30/10305.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i30.10305

Full Article (PDF)	WJG-20-10305.pdf
Full Article (Word)	WJG-20-10305.doc
Manuscript File	7341-Review.docx
Answering Reviewers	7341-Answering reviewers.pdf
Copyright License Agreement	7341-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7341-Language certificate.pdf
Peer-review Report	7341-Peer reviews.pdf
Scientific Editor Work List	7341-Scientific editor work list.doc