Publication Name	World Journal of Gastroenterology
Manuscript ID	7345
Country	China

Received	2013-11-14 08:06
Peer-Review Started	2013-11-15 09:41
To Make the First Decision	2013-12-16 17:16
Return for Revision	2013-12-17 13:51
Revised	2014-01-16 21:02
Second Decision	2014-04-03 10:17
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-03 12:34
Articles in Press	2014-05-23 11:00
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-05-09 07:25
Typeset the Manuscript	2014-06-24 16:25
Publish the Manuscript Online	2014-07-14 17:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Hematology
Manuscript Type	Autobiography
Article Title	Zinc protoporphyrin IX enhances chemotherapeutic response of hepatoma cells to cisplatin
Manuscript Source	Invited Manuscript
All Author List	Yang-Sui Liu, Huan-Song Li, Dun-Feng Qi, Jun Zhang, Xin-Chun Jiang, Kui Shi, Xiao-Jun Zhang and Xin-Hui Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Xuzhou City Health Bureau Project, China XZZD1128 Xuzhou City Municipal Science and Technology Bureau Project, China XWJ2011040
Corresponding Author	Xin-Hui Zhang, MD, The Central Hospital of Xuzhou City, Xuzhou Hospital Affiliated to Medical College of Southeast University, Jiefang Rd, Xuzhou 221009, Jiangsu Province, China. 88liuyin888@163.com
Key Words	Zinc protoporphyrin IX; Heme oxygenase-1; Liver cancer cell lines; Cisplatin; Chemotherapy
Core Tip	Overexpression of heme oxygenase (HO)-1 in HepG2 cell line was associated with increased chemoresistance to cis-diaminedichloroplatinum (cisplatin; CDDP) compared to other cell lines. Inhibition of HO-1 expression by zinc protoporphyrin IX (ZnPP IX) markedly augmented CDDP-mediated cytotoxicity towards other hepatoma cells. Induction of HO-1 with hemin increased resistance of tumor cells to CDDP-mediated cytotoxicity. Furthermore, cells treated with ZnPP IX plus CDDP exhibited marked production of intracellular reactive oxygen species (ROS) and caspase-3 activity, whereas hemin decreased cellular ROS and caspase-3 activity induced by CDDP. Therefore, administration of HO-1 inhibitors may evolve into a new liver cancer treatment strategy.
Publish Date	2014-07-14 17:39
Citation	Liu YS, Li HS, Qi DF, Zhang J, Jiang XC, Shi K, Zhang XJ, Zhang XH. Zinc protoporphyrin IX enhances chemotherapeutic response of hepatoma cells to cisplatin. World J Gastroenterol 2014; 20(26): 8572-8582
URL	http://www.wjgnet.com/1007-9327/full/v20/i26/8572.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i26.8572

Full Article (PDF)	WJG-20-8572.pdf
Full Article (Word)	WJG-20-8572.doc
Manuscript File	7345-Review.doc
Answering Reviewers	7345-Answering reviewers.pdf
Copyright License Agreement	7345-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7345-Language certificate.pdf
Peer-review Report	7345-Peer reviews.pdf
Scientific Editor Work List	7345-Scientific editor work list.doc