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Articles Published Processes
3/30/2022 3:20:26 PM | Browse: 738 | Download: 1681
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Received |
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2021-11-23 22:26 |
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Peer-Review Started |
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2021-11-23 22:28 |
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First Decision by Editorial Office Director |
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2022-01-08 18:46 |
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Return for Revision |
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2022-01-08 18:46 |
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Revised |
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2022-01-17 03:04 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2022-02-24 06:10 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2022-02-27 23:16 |
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Articles in Press |
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2022-02-27 23:16 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-03-23 11:33 |
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Publish the Manuscript Online |
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2022-03-30 15:20 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pathology |
| Manuscript Type |
Basic Study |
| Article Title |
c-MET immunohistochemical expression in sporadic and inflammatory bowel disease associated lesions
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Grant Halliday, Ross J Porter, Catherine J Black, Mark J Arends and Shahida Din |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Shahida Din, BSc, FRCP, MBChB, PhD, Consultant Physician-Scientist, Edinburgh Inflammatory Bowel Disease Unit, Western General Hospital, NHS Lothian, Anne Feguson Building
, Edinburgh EH4 2XU, United Kingdom. sdin@exseed.ed.ac.uk |
| Key Words |
Inflammatory bowel diseases; Colorectal cancer; Surveillance; Detection; c-MET; Immunohistochemistry |
| Core Tip |
During colonoscopy, an intravenous fluorescent anti-c-MET probe may improve endoscopic detection of dysplasia and cancer. However, c-MET expression in inflammatory bowel disease (IBD) lesions is poorly defined, limiting translational studies. We demonstrate that stronger immunohistochemical c-MET expression is associated with dysplasia and cancer in both sporadic and IBD-associated lesions. Therefore, c-MET expression could be exploited clinically to enhance endoscopic detection of pre-malignant lesions and cancer, particularly in IBD where post-colonoscopy colorectal cancer rates are unacceptably high. |
| Publish Date |
2022-03-30 15:20 |
| Citation |
Halliday G, Porter RJ, Black CJ, Arends MJ, Din S. c-MET immunohistochemical expression in sporadic and inflammatory bowel disease associated lesions. World J Gastroenterol 2022; 28(13): 1338-1346 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i13/1338.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i13.1338 |
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